DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31371 and CG15539

DIOPT Version :9

Sequence 1:	NP_733375.2	Gene:	CG31371 / 43626	FlyBaseID:	FBgn0051371	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	132/546 - (24%)
Similarity:	220/546 - (40%)	Gaps:	132/546 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPVVFSVLWLLQLFLLVES-----VAGANFARGEEQLQALLDTETQLIDGLRDYIERLERQLEEI 60
            ||.:...|.:|.|.:||:|     :...|:|.....:..|:|.|..|::.|:.:...|::
  Fly     1 MPKLLISLAILYLLVLVKSHSKPKILENNYAISIYDMSKLIDYEHYLLNILQKFANALQK----- 60

  Fly    61 RRETSAIEEIHSQVDSVEEYM------------GNPLNVFGILKRFES-----VWPGLEQKANAT 108
                        :||::|.|:            .:|:..|.|.:|..|     || .:|::...|
  Fly    61 ------------RVDTLEYYLEMTDYDREKNLAEDPIKHFRITRRLHSDYVNWVW-FMEEQPWGT 112

  Fly   109 L---------EMVFGERLSDRQLTLPSEEDYEESLNHLLHLQSVYELDSNSLSLGVVNGFKLGSS 164
            |         ||             |:.:|.||::..|..:|..|.|.:..::.||:......:|
  Fly   113 LVKDIIAIAPEM-------------PTLKDVEEAIRGLRLIQWTYSLPTAEMAKGVLQDIHHNTS 164

  Fly   165 MSWGDCLEVARK----SDFPVARFWLESALEKLPSASENSTESQRERESGRVHILEATLNIEYRA 225
            :....|:.:||.    .||..|:.||...| |:..|.|.......:.....|...|..:.|:...
  Fly   165 LDGMQCITIARHMVNYKDFIRAKEWLMVGL-KMYEADEEIEYIYSQLGMPLVDFYELFVEIQDEL 228

  Fly   226 GELSRALATAEELLLLLPMNQGIQKAKRKIEKAMAKKELPKGRGQKSKAKKQISKSTEQLLIEEI 290
            |  ||.||.:|   |.|.:....:|.  .:::|:::.::....|::...||..||...:......
  Fly   229 G--SRYLAMSE---LQLAIKNWPEKV--SLQRALSRLKMNIRIGKEPAEKKNKSKRVYKKCCSSE 286

  Fly   291 CRGAKQ----QVTTGSRFNHCQLDGSSPWLLLQPSRLEPVSSDPYIVLHHDVLTPKESNELLQLI 351
            ||...:    ..||.|.|           |.|.|.::|.:|.|||:||.|||::.|:...:..|.
  Fly   287 CRPTAKLYCLYKTTSSYF-----------LRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRNLT 340

  Fly   352 ------------------DEEEDTKG---VSYQSL--KLSKLAQKKLGRISRLLGLEILELDPWT 393
                              |.:..|||   |...:|  :||:|.|.       :...:|.:.||:.
  Fly   341 KGKLARTVTVSKDGNYTEDPDRTTKGTWLVENNALIQRLSQLTQD-------MTNFDIHDADPFQ 398

  Fly   394 GRRHG-----HEHITKLEHSSELKH----VARLMLNLQAPGMGGAVVFPQLELAVNVPRGSLLHW 449
            ...:|     ..|...|| .:||.:    :|..:..|.....|||.:||:|.|:|...:||.|.|
  Fly   399 VLNYGIGGFYGIHFDFLE-DAELDNFSDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKGSALLW 462

  Fly   450 RTRFAGGSSSEWDYRSGQAICPVLLG 475
               :......:.|.|:..:.||.::|
  Fly   463 ---YNLDHKGDGDNRTAHSACPTVVG 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31371	NP_733375.2	P4Ha_N	30..156	CDD:285528	31/151 (21%)
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	31/153 (20%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	40/168 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391515at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	7	6.850