DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31371 and P4ha2

DIOPT Version :9

Sequence 1:	NP_733375.2	Gene:	CG31371 / 43626	FlyBaseID:	FBgn0051371	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	131/519 - (25%)
Similarity:	231/519 - (44%)	Gaps:	64/519 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLWLLQLFLLVESVAGANFARGEEQLQALLDTETQLIDGLRDYIERLERQLEEIRRETSAIEEIH 71
            ||.||..:..|.|...|.|......:..|:..|..|:..|::||...|.:|.:|:...|.:|.:.
  Rat     5 VLVLLMSWFGVLSWVQAEFFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEALT 69

  Fly    72 SQ-VDSVEEYMGNPLNVFGILKRFESVWPGLEQKANATLEMVFGERLSDRQLTLPSEEDYEESLN 135
            |: ....|.|:.:|:|.:.::||..:.||.|...........|...||.::...|::||...:..
  Rat    70 SKSAADPEGYLAHPVNAYKLVKRLNTDWPALGDLVLQDAAAGFVANLSVQRQFFPTDEDESGAAR 134

  Fly   136 HLLHLQSVYELDSNSLSLGVVNGFKLGSSMSWGDCLEVAR----KSDFPVARFWLESALEKLPSA 196
            .|:.||..|:||.:.:|.|.:.|.|..:.:|..||..:.|    :.|:.....|:|..|::| .|
  Rat   135 ALMRLQDTYKLDPDMISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQL-DA 198

  Fly   197 SENSTESQRERESGRVHILEATLNIEYRAGELSRALATAEELLLLLPMNQ----GIQKAKRKIEK 257
            .|.:|.:       :..:|:......::.|:|.||:.....||.|.|.::    .::..:|.:|:
  Rat   199 GEEATVT-------KSLVLDYLSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGNLRYFERLLEE 256

  Fly   258 AMAK---KELPKG-RGQKSKAKKQISKSTEQLLIEEICRG------AKQQVTTGSRFNHCQLDGS 312
            ...|   .:...| ..|::..::.:....|:.:.|.:|||      .::|.....|::|   ...
  Rat   257 ERGKSLSNQTDAGLASQENLYERPVDYLPERDVYESLCRGEGIKMTPRRQKRLFCRYHH---GNR 318

  Fly   313 SPWLLLQPSRLEPVSSDPYIVLHHDVLTPKESNELLQLIDEE------EDTK-GV----SYQSLK 366
            .|.||:.|.:.|.....|:||.::||::.:|...:.::...:      .|.| ||    ||:..|
  Rat   319 VPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSK 383

  Fly   367 LSKLAQKK---LGRISR----LLGL-----EILELDPW--TGRRHGHEHITKLEHSSELK----- 412
            .|.|.:..   :.|::|    :.||     |:|::..:  .|:...|...::.:.....|
  Rat   384 SSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRSDERDAFKRLGTG 448

  Fly   413 -HVARLMLNLQAPGMGGAVVFPQLELAVNVPRGSLLHWRTRFAGGSSSEWDYRSGQAICPVLLG 475
             .||..:..:.....|||.|||.|..|:...:|:.:.|......|   |.|||:..|.||||:|
  Rat   449 NRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSG---EGDYRTRHAACPVLVG 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31371	NP_733375.2	P4Ha_N	30..156	CDD:285528	35/126 (28%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	21/76 (28%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	42/167 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391515at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920