DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31371 and P4ha1

DIOPT Version :9

Sequence 1:	NP_733375.2	Gene:	CG31371 / 43626	FlyBaseID:	FBgn0051371	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001303300.1	Gene:	P4ha1 / 18451	MGIID:	97463	Length:	534	Species:	Mus musculus

Alignment Length:	527	Identity:	127/527 - (24%)
Similarity:	234/527 - (44%)	Gaps:	77/527 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLW--LLQLFLLVESVAGANFARGEEQLQALLDTETQLIDGLRDYIERLERQLEEIRRETSAIEE 69
            ::|  |:...||.:|:|...|.....|:..|:..|..|:..|:|||:..|.:||:|::....::.
Mouse     1 MIWVVLMMAILLPQSLAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDR 65

  Fly    70 IHS-QVDSVEEYMGNPLNVFGILKRFESVWPGLEQKANATLEMVFGERLSDRQLTLPSEEDYEES 133
            :.| .....|.::|:|:|.|.::||..:.|..||......:...|...|:.::...|::||...:
Mouse    66 LTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMSDGFISNLTIQRQYFPNDEDQVGA 130

  Fly   134 LNHLLHLQSVYELDSNSLSLGVVNGFKLGSSMSWGDCLEVAR----KSDFPVARFWLESALEKLP 194
            ...|..||..|.||:|::|.|.:.|.:..|.::..||.|:.:    ::|:.....|:|.||.:|.
Mouse   131 AKALFRLQDTYNLDTNTISKGNLPGVQHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALTQLE 195

  Fly   195 SASENSTESQRERESGRVHILEATLNIEYRAGELSRALATAEELLLLLPMNQGIQKAKRKIEKAM 259
            ....::.:        :|.:|:......|:.|:|.:||...::||.|.|.:|.........|..|
Mouse   196 EGELSTVD--------KVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIM 252

  Fly   260 AK-KELPKGRG-----QKSKAKKQ---ISKSTEQLLIEEICRG------AKQQVTTGSRFNHCQL 309
            :| |:..|...     ||:..||:   :....|:...|.:|||      .::|.....|::
Mouse   253 SKEKDANKSASGDQSDQKTAPKKKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYH---- 313

  Fly   310 DGS-SPWLLLQPSRLEPVSSDPYIVLHHDVLTPKESNELLQLIDE------------EEDTKGVS 361
            ||: :|..:|.|::.|.....|.|:..||:::..|    ::::.:            :.:|..::
Mouse   314 DGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAE----IEIVKDLAKPRLSRATVHDPETGKLT 374

  Fly   362 YQSLKLSKLA----------QKKLGRISRLLGLEILELDPWTGRRHG-------HEHITKLEHSS 409
            ....::||.|          .:...||..|.||::...:......:|       |....:.:...
Mouse   375 TAQYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPD 439

  Fly   410 ELK------HVARLMLNLQAPGMGGAVVFPQLELAVNVPRGSLLHWRTRFAGGSSSEWDYRSGQA 468
            ..:      .:|..:..:.....|||.|||::..:|...:|:.:.|...||.|   |.||.:..|
Mouse   440 AFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASG---EGDYSTRHA 501

  Fly   469 ICPVLLG 475
            .||||:|
Mouse   502 ACPVLVG 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31371	NP_733375.2	P4Ha_N	30..156	CDD:285528	37/126 (29%)
P4ha1	NP_001303300.1	P4Ha_N	24..153	CDD:285528	37/128 (29%)
		TPR	205..238		11/32 (34%)
		P4Hc	345..518	CDD:214780	34/171 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910