DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31371 and dpy-18

DIOPT Version :9

Sequence 1:	NP_733375.2	Gene:	CG31371 / 43626	FlyBaseID:	FBgn0051371	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_499464.1	Gene:	dpy-18 / 176569	WormBaseID:	WBGene00001077	Length:	559	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	128/547 - (23%)
Similarity:	217/547 - (39%)	Gaps:	124/547 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LQLFLLVESVAG---ANFARGEEQLQALLDTETQLIDGLRDYI----ERLERQLEEIRRETSAIE 68
            ::|.|||.:..|   |:.......:|.||:||..:...|..||    |||. ||:::..|.|...
Worm     1 MRLALLVLATIGYAVADLFTSIADMQNLLETERNIPKILDKYIHDEEERLV-QLKKLSEEYSKKN 64

  Fly    69 EIHSQVDSVEEYMGNPLNVFGILKRFESVWPGLEQKANATLEMVFGERLSDRQ--LTLPSEEDYE 131
            ||  .:::..:.:.||:|.|.::||....|..:|.|.||.........::|..  :..|:.:|..
Worm    65 EI--SIENGLKDITNPINAFLLIKRKIFDWKEIESKMNANKAGNVVSSITDDSYGVRYPTADDLS 127

  Fly   132 ESLNHLLHLQSVYELDSNSLSLGVVNGFKLGSSMSWGDCLEVAR----KSDFPVARFWLESALEK 192
            .:...||.||..|.||:..|:.|.:...:...:.|..||.|:||    :.||.....|:|.|..:
Worm   128 GAAIGLLRLQDTYRLDTKDLADGKIYADQGNYTFSAKDCFEIARAAYNEHDFYHTVMWMEEAQRR 192

  Fly   193 LPSASENSTESQRERESGRVHILEATLNIEYRAGELSRALATAEELLLLLPMNQGIQKAKRKIE- 256
            |....|.:.|.:        .|||......|:...|..||...||   |..||....:||..::
Worm   193 LGDEVEPTVEVE--------DILEYLAFALYKQNNLKHALKLTEE---LYKMNPTHPRAKGNVKW 246

  Fly   257 -----------KAMAKKELPKGRGQKSKAKKQISKSTEQLLIEEICRG----AKQQVTTGSRFNH 306
                       ::..:|.||..:.::..:   :..:||:.:.|.:||.    :::.:   ||. :
Worm   247 YEDLLEQEGVRRSDMRKNLPPIQNRRPDS---VLGNTERTMYEALCRNEVPVSQKDI---SRL-Y 304

  Fly   307 CQLDGSSPWLLLQPSRLEPVSSDPYIVLHHDVLTPKESNELLQLIDEEEDTKGVSYQSLKLSKLA 371
            |......|:|:..|.::|....:|..||..||::               |.:..:.|.|...|||
Worm   305 CYYKRDRPFLVYAPIKVEIKRFNPLAVLFKDVIS---------------DDEVAAIQELAKPKLA 354

  Fly   372 QKKLG------------RISRLLGLEILELDPWTG-------RRHGHEHITKLEHSSELK----- 412
            :..:.            |||:...|:     .|.|       :|.|:....::|.:.||:
Worm   355 RATVHDSVTGKLVTATYRISKSAWLK-----EWEGDVVETVNKRIGYMTNLEMETAEELQIANYG 414

  Fly   413 ---------------------------HVARLMLNLQAPGMGGAVVFPQLELAVNVPRGSLLHWR 450
                                       .:|.::..:..|..||..||.:.:..:...:...|.|.
Worm   415 IGGHYDPHFDHAKKEESKSFESLGTGNRIATVLFYMSQPSHGGGTVFTEAKSTILPTKNDALFWY 479

  Fly   451 TRFAGGSSSEWDYRSGQAICPVLLGVQ 477
            ..:..|..:. |.|  .|.||||:|::
Worm   480 NLYKQGDGNP-DTR--HAACPVLVGIK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31371	NP_733375.2	P4Ha_N	30..156	CDD:285528	40/131 (31%)
dpy-18	NP_499464.1	P4Ha_N	21..152	CDD:285528	40/133 (30%)
dpy-18	NP_499464.1	P4Hc	338..511	CDD:214780	34/189 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391515at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920