DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31371 and p4ha1b

DIOPT Version :9

Sequence 1:	NP_733375.2	Gene:	CG31371 / 43626	FlyBaseID:	FBgn0051371	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_999856.1	Gene:	p4ha1b / 100003675	ZFINID:	ZDB-GENE-030131-4089	Length:	536	Species:	Danio rerio

Alignment Length:	548	Identity:	129/548 - (23%)
Similarity:	227/548 - (41%)	Gaps:	123/548 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WLLQLFLLVESVAGANFARGEEQLQALLDTETQLIDGLRDYIERLERQLEEIRRETSAIEEIH-S 72
            |.|..||.....|..:|.....|:..||..|..|:..|::||::.|.:||:::.....::.:. :
Zfish     5 WFLLSFLFHFLYAHNDFFTSTGQMTDLLYAEKDLVTSLKEYIKQEENRLEQVKEWADKLDSLTIT 69

  Fly    73 QVDSVEEYMGNPLNVFGILKRFESVWPGLEQKANATLEMVFGERLSDRQLTLPSEEDYEESLNHL 137
            .....|.::|:|:|.|.::||..|.|..||..........|...|:.::...|::||...:...|
Zfish    70 ATQDPEGFLGHPVNAFKLMKRLNSEWSDLENLVLKDTTNGFISNLTVQRQYFPTDEDQTGAAKAL 134

  Fly   138 LHLQSVYELDSNSLSLGVVNGFKLGSSMSWGDCLEVAR----KSDFPVARFWLESALEKLPSASE 198
            |.||..|:|.:|::|.|.:.|....|.|:..||.|:.:    .:|:.....|:..||.:|....|
Zfish   135 LRLQDTYQLSANAISSGDLPGVVHKSRMTVEDCYELGKIAYSDADYYHTELWMAQALSQLDEGEE 199

  Fly   199 NSTESQRERESGRVHILEATLNIEYRAGELSRALATAEELLLLLPMN--------------QGIQ 249
            :..:        :|.:::......|:.|||.|||...:.:|.|.|.:              :..:
Zfish   200 SPID--------KVTVMDYLSYAIYQQGELDRALELTKRMLKLDPNHHRANGNLKYFEFQLEKQR 256

  Fly   250 KAKRKIEKAMAKKELPKGRGQKSKAKKQISKSTEQLLIEEICRG------AKQQVTTGSRFNHCQ 308
            ||:.:.::...|:.|.|...|:.::|..:   .|:...|.:|||      .::|.....|:::
Zfish   257 KAENEKKEEDQKRVLDKRDAQRKRSKDPL---PERKKYERLCRGEGIKLTPRRQSRLFCRYSN-- 316

  Fly   309 LDGSSPWLLLQPSRLEPVSSDPYIVLHHDVLTPKESNELLQLIDEEEDTKGVSYQSLKLSKLAQK 373
             :..:|.|||.|.:.|.....|.||.:|::::           |.|.:|         :.::|:.
Zfish   317 -NNRNPRLLLAPVKQEDEWDRPRIVRYHEIIS-----------DSEIET---------VKEMAKP 360

  Fly   374 KLGR--ISR-LLGLEILELDP-------WTGRRHGHEHIT--------------KLEHSSELK-- 412
            :|.|  ||. :.|  :||..|       |..   |:||.|              :::.:.||:
Zfish   361 RLRRATISNPITG--VLETAPYRISKSAWLS---GYEHSTIERINQRIEDVTGLEMDTAEELQVA 420

  Fly   413 ------------------------------HVARLMLNLQAPGMGGAVVFPQLELAVNVPRGSLL 447
                                          .:|..:..:.....|||.||..:..||...:|:.:
Zfish   421 NYGVGGQYEPHFDFGRKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFTDVGAAVWPKKGTAV 485

  Fly   448 HWRTRFAGGSSSEWDYRSGQAICPVLLG 475
            .|...|..|   |.||.:..|.||||:|
Zfish   486 FWYNLFPSG---EGDYSTRHAACPVLVG 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31371	NP_733375.2	P4Ha_N	30..156	CDD:285528	36/126 (29%)
p4ha1b	NP_999856.1	P4Ha_N	24..153	CDD:285528	36/128 (28%)
		TPR repeat	164..199	CDD:276809	8/34 (24%)
		TPR_16	168..238	CDD:290168	18/77 (23%)
		TPR repeat	204..234	CDD:276809	9/29 (31%)
		P4Hc	347..520	CDD:214780	40/192 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391515at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920