DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE1 and P4htm

DIOPT Version :9

Sequence 1:	NP_733374.1	Gene:	PH4alphaNE1 / 43625	FlyBaseID:	FBgn0039780	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_083220.3	Gene:	P4htm / 74443	MGIID:	1921693	Length:	503	Species:	Mus musculus

Alignment Length:	432	Identity:	106/432 - (24%)
Similarity:	152/432 - (35%)	Gaps:	161/432 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 LNGVKYGSD-----MSWQDCF----ELGQQLFEMEDYNNTK-----VWLRESMERLRRQTSHAPS 205
            |.|:|.|.:     ::.:|.|    .|...|||:..:.:.:     :.|.: |:.|:|      |
Mouse   115 LEGIKVGYERKVQVVAGRDHFIRTLSLKPLLFEIPGFLSDEECRLIIHLAQ-MKGLQR------S 172

  Fly   206 HLAPTSGPDTVTLNKMEATAKSLFQLGD--FDTAFELSQRVLQFDPKRIRNWHLGDKGTAPPEDI 268
            .:.||...:. .::.|:.:...||||.|  .|...:|.:.:.|        ..||:.....||:|
Mouse   173 QILPTEEYEE-AMSAMQVSQLDLFQLLDQNHDGRLQLREVLAQ--------TRLGNGRWMTPENI 228

  Fly   269 DDVYL-----PKHSDSYSLSQEFAKYEKVCRGEVHPIVRQELRCRYSRGNHPYRFLAPLKLEEHS 328
            .::|.     |......|| |||:              ..:||
Mouse   229 QEMYSAIKADPDGDGVLSL-QEFS--------------NMDLR---------------------- 256

  Fly   329 LDPYVATFHDILSPGKISQLREMAVPRMHRSTVNPLPGGQLKKSAFRVSKNAWL--AYESHPTMV 391
                  .||..:              |.|::..|.|         .|.|.:.||  ...:|..|.
Mouse   257 ------DFHKYM--------------RSHKAESNEL---------VRNSHHTWLHQGEGAHHVMR 292

  Fly   392 GMLRDLKDATGLD---TTFCEQLQVANYGVGGHYEPHWDFFRDP-------NH--------YPAE 438
            .:.:.:...|.|.   ..|.|.|||..||.||||..|.|  ..|       :|        .|.|
Mouse   293 AIRQRVLRLTRLSPEIVEFSEPLQVVRYGEGGHYHAHVD--SGPVYPETICSHTKLVANESVPFE 355

  Fly   439 EGNRIATAIFYLSEVEQGGATAFPFLD---------------------------IAVKPQLGNVL 476
            ...|..|.:|||:.|..||.|.||..|                           :.||||.|..:
Mouse   356 TSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAV 420

  Fly   477 FWYNL-------HRSLDKDYRTKHAGCPVLKGSKWIGNVWIH 511
            ||||.       ...:| || :.|.||.|.:|:|||.|.||:
Mouse   421 FWYNYLPDGQGWVGEVD-DY-SLHGGCLVTRGTKWIANNWIN 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	106/432 (25%)
PH4alphaNE1	NP_733374.1	P4Hc	341..511	CDD:214780	63/223 (28%)
P4htm	NP_083220.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..110
		EF-hand_7	193..253	CDD:290234	20/82 (24%)
		EFh	195..253	CDD:298682	19/80 (24%)
		P4Hc	247..459	CDD:214780	70/281 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839367
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740