Protein Alignment PH4alphaNE1 and P4ha1

DIOPT Version :10

• Sequence 1: NP_733374.1
• Gene: PH4alphaNE1 / 43625
• FlyBaseID: FBgn0039780
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_742059.2
• Gene: P4ha1 / 64475
• RGDID: 621000
• Length: 534
• Species: Rattus norvegicus
• Alignment Length: 555
• Identity: 207/555 - (37%)
• Similarity: 317/555 - (57%)
• Gaps: 69/555 - (12%)

  Fly     5 VLLVGLIFLLAQGSLASDYFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSSIEKEH 69
            ||::|:  ||.|.|....:|:||..:.||:|.|:.|...|:..:.|.:..|:|::.....:::..
  Rat     5 VLMMGI--LLPQCSAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLT 67

  Fly    70 TMAASDTENYLTNPVNVYRLMKRLHTDWSLMEGRVQLMAEEM------NFNATREYGLSYPSQED 128
            :.|..|.|.::.:|||.::|||||:|:||.:|   .|:.::|      |....|:|   :|:.||
  Rat    68 STATKDPEGFVGHPVNAFKLMKRLNTEWSELE---NLILKDMSDGFISNLTIQRQY---FPNDED 126

  Fly   129 VEGAALALVRLQSTYKLDVAQVAQGILNGVKYGSDMSWQDCFELGQQLFEMEDYNNTKVWLRESM 193
            ..|||.||.|||.||.||...:::|.|.|||:.|.::.:||||||:..:...||.:|::|:.:::
  Rat   127 QVGAAKALFRLQDTYNLDTNTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQAL 191

  Fly   194 ERLRRQTSHAPSHLAPTSGPDTVTLNKMEATAKSLFQLGDFDTAFELSQRVLQFDPKRIR-NWHL 257
            .:|..         ...|..|.|::  ::..:.:::|.||.|.|..|::::|:.||:..| |.:|
  Rat   192 MQLEE---------GEMSTVDKVSV--LDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNL 245

  Fly   258 ---------------------GDKGTAPPED---IDDVYLPKHSDSYSLSQEFAKYEKVCRGE-- 296
                                 .|:.|.|.:.   :|  |||          |..|||.:||||
  Rat   246 VYFEYIMSKEKDANKSASGDQSDQKTTPKKKGIAVD--YLP----------ERQKYEMLCRGEGI 298

  Fly   297 -VHPIVRQELRCRYSRGN-HPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRS 359
             :.|..::.|.|||..|| :|...|||.|.|:....|.:..||||:|..:|..::::|.||:.|:
  Rat   299 KMTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRA 363

  Fly   360 TVNPLPGGQLKKSAFRVSKNAWLAYESHPTMVGMLRDLKDATGLDTTFCEQLQVANYGVGGHYEP 424
            ||:....|:|..:.:||||:|||:....|.:..:...::|.||||.:..|:||||||||||.|||
  Rat   364 TVHDPETGKLTTAQYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEP 428

  Fly   425 HWDFFR--DPNHY-PAEEGNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSLD 486
            |:||.|  :|:.: ....||||||.:||:|:|..||||.||.:..:|.|:.|..:|||||..|.:
  Rat   429 HFDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGE 493

  Fly   487 KDYRTKHAGCPVLKGSKWIGNVWIHEVTQTFARPC 521
            .||.|:||.||||.|:||:.|.|:||..|.|.|||
  Rat   494 GDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPC 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..157	CDD:462433	48/136 (35%)
		P4Hc	341..511	CDD:214780	81/172 (47%)
P4ha1	NP_742059.2	P4Ha_N	24..155	CDD:462433	48/136 (35%)
		TPR	205..238		10/34 (29%)
		P4Hc	345..518	CDD:214780	81/172 (47%)