DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE1 and P4ha1

DIOPT Version :9

Sequence 1:	NP_733374.1	Gene:	PH4alphaNE1 / 43625	FlyBaseID:	FBgn0039780	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_742059.2	Gene:	P4ha1 / 64475	RGDID:	621000	Length:	534	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	207/555 - (37%)
Similarity:	317/555 - (57%)	Gaps:	69/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLLVGLIFLLAQGSLASDYFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSSIEKEH 69
            ||::|:  ||.|.|....:|:||..:.||:|.|:.|...|:..:.|.:..|:|::.....:::..
  Rat     5 VLMMGI--LLPQCSAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLT 67

  Fly    70 TMAASDTENYLTNPVNVYRLMKRLHTDWSLMEGRVQLMAEEM------NFNATREYGLSYPSQED 128
            :.|..|.|.::.:|||.::|||||:|:||.:|   .|:.::|      |....|:|   :|:.||
  Rat    68 STATKDPEGFVGHPVNAFKLMKRLNTEWSELE---NLILKDMSDGFISNLTIQRQY---FPNDED 126

  Fly   129 VEGAALALVRLQSTYKLDVAQVAQGILNGVKYGSDMSWQDCFELGQQLFEMEDYNNTKVWLRESM 193
            ..|||.||.|||.||.||...:::|.|.|||:.|.::.:||||||:..:...||.:|::|:.:::
  Rat   127 QVGAAKALFRLQDTYNLDTNTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQAL 191

  Fly   194 ERLRRQTSHAPSHLAPTSGPDTVTLNKMEATAKSLFQLGDFDTAFELSQRVLQFDPKRIR-NWHL 257
            .:|..         ...|..|.|::  ::..:.:::|.||.|.|..|::::|:.||:..| |.:|
  Rat   192 MQLEE---------GEMSTVDKVSV--LDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNL 245

  Fly   258 ---------------------GDKGTAPPED---IDDVYLPKHSDSYSLSQEFAKYEKVCRGE-- 296
                                 .|:.|.|.:.   :|  |||          |..|||.:||||
  Rat   246 VYFEYIMSKEKDANKSASGDQSDQKTTPKKKGIAVD--YLP----------ERQKYEMLCRGEGI 298

  Fly   297 -VHPIVRQELRCRYSRGN-HPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRS 359
             :.|..::.|.|||..|| :|...|||.|.|:....|.:..||||:|..:|..::::|.||:.|:
  Rat   299 KMTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRA 363

  Fly   360 TVNPLPGGQLKKSAFRVSKNAWLAYESHPTMVGMLRDLKDATGLDTTFCEQLQVANYGVGGHYEP 424
            ||:....|:|..:.:||||:|||:....|.:..:...::|.||||.:..|:||||||||||.|||
  Rat   364 TVHDPETGKLTTAQYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEP 428

  Fly   425 HWDFFR--DPNHY-PAEEGNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSLD 486
            |:||.|  :|:.: ....||||||.:||:|:|..||||.||.:..:|.|:.|..:|||||..|.:
  Rat   429 HFDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGE 493

  Fly   487 KDYRTKHAGCPVLKGSKWIGNVWIHEVTQTFARPC 521
            .||.|:||.||||.|:||:.|.|:||..|.|.|||
  Rat   494 GDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPC 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	47/134 (35%)
PH4alphaNE1	NP_733374.1	P4Hc	341..511	CDD:214780	81/172 (47%)
P4ha1	NP_742059.2	P4Ha_N	25..112	CDD:400573	27/89 (30%)
		TPR	205..238		10/34 (29%)
		P4Hc	345..518	CDD:214780	81/172 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830