DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE1 and CG15864

DIOPT Version :9

Sequence 1:	NP_733374.1	Gene:	PH4alphaNE1 / 43625	FlyBaseID:	FBgn0039780	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	159/542 - (29%)
Similarity:	244/542 - (45%)	Gaps:	99/542 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVGLI---FLLAQGSLASD----YFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSS 64
            |:|.:   |:..||.:.|:    |.:|...|..||..|..|...|:..|..::.....:|..|..
  Fly     9 LIGFLSACFINCQGFVKSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLID 73

  Fly    65 IEKEHTMAASDTENYLTNPVNVYRLMKRLHTDWSLMEGRVQLMAEEMNFNA------TREYGLSY 123
            :.:|:....||.|:||.||:|.:||:.||||.|.    :....|.::..||      .|......
  Fly    74 MSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWR----KWYQYAIKVENNALGHIENARLMRKML 134

  Fly   124 PSQEDVEGAALALVRLQSTYKLDVAQVAQGILNGVKY-GSDMSWQDCFELGQQLFEMEDYNNTKV 187
            |:..|::.|...:..|.|.|.|...::|.|.|.|... |:.::..||..||:...:..:.:..:.
  Fly   135 PTSSDLQQACRGIHDLMSFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFSVQKREDDLAEA 199

  Fly   188 WLRESMERLRRQTSHAPSHLAPTSGPDTVTLNKMEATAKSLFQLGDFDTAFELSQRVLQFDPKRI 252
            |...|:.|...:......|.|         ...:.|..|   ||.|   ||
  Fly   200 WYNLSLIRFENKFDKYRVHKA---------WGLLLAKNK---QLTD---AF-------------- 235

  Fly   253 RNWHLGDKGTAPPEDIDDVYLPKHSDSYSLSQEFAKY-EKVCRGEVHPIVRQE---LRCRYSRGN 313
              :|..:|    ||.|            ..|.|...: |::...:...:|.|:   |.|||:...
  Fly   236 --YHFENK----PEGI------------IASNEVIHFKEELSTKQNCAVVVQKPSRLHCRYNTTT 282

  Fly   314 HPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRST--VNPLPGGQLKKSAFRV 376
            .|:..:||||:||..||||:..|||::...:|..:       ::.|.  ::....||  ||..|.
  Fly   283 TPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGM-------LNSSNFGLSLTDSGQ--KSEVRT 338

  Fly   377 SKNAWLAYESHPTMVGMLRDLK-------DATGLDTTFCEQLQVANYGVGGHYEPHWDFFRDPNH 434
            ||::::.            |.|       |.||......:...:.|||:||||..|:||....|.
  Fly   339 SKDSYIV------------DAKTLNERVTDMTGFSMEMSDPFSLINYGLGGHYMLHYDFHEYTNT 391

  Fly   435 YPAEEGNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSLDKDYRTKHAGCPVL 499
            ...::|:||||.:|||.||:.||||.||.::|.|.|:.|:.:||||||.|...:.::.|:.|||:
  Fly   392 TRPKQGDRIATVLFYLGEVDSGGATIFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVI 456

  Fly   500 KGSKWIGNVWIHEVTQTFARPC 521
            .|||::...||:|:.|.|..||
  Fly   457 SGSKYVLTKWINELPQMFVTPC 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	39/134 (29%)
PH4alphaNE1	NP_733374.1	P4Hc	341..511	CDD:214780	60/178 (34%)
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	39/134 (29%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	25/84 (30%)
		P4Hc	313..467	CDD:214780	59/174 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461806
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900