DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE1 and CG15539

DIOPT Version :9

Sequence 1:	NP_733374.1	Gene:	PH4alphaNE1 / 43625	FlyBaseID:	FBgn0039780	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	168/568 - (29%)
Similarity:	255/568 - (44%)	Gaps:	110/568 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRGLVLLVGLIFLLA-------QGSLASDYFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQL 58
            |..|::.:.:::||.       ...|.::|..||..:..|:..|.||...|:...||:|..:..|
  Fly     1 MPKLLISLAILYLLVLVKSHSKPKILENNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTL 65

  Fly    59 E--SELSSIEKEHTMAASDTENYLTNPVNVYRLMKRLHTD------------WSLMEGRVQLMAE 109
            |  .|::..::|        :|...:|:..:|:.:|||:|            |..:...:..:|.
  Fly    66 EYYLEMTDYDRE--------KNLAEDPIKHFRITRRLHSDYVNWVWFMEEQPWGTLVKDIIAIAP 122

  Fly   110 EMNFNATREYGLSYPSQEDVEGAALALVRLQSTYKLDVAQVAQGILNGVKYGSDMSWQDCFELGQ 174
            ||            |:.:|||.|...|..:|.||.|..|::|:|:|..:.:.:.:....|..:.:
  Fly   123 EM------------PTLKDVEEAIRGLRLIQWTYSLPTAEMAKGVLQDIHHNTSLDGMQCITIAR 175

  Fly   175 QLFEMEDYNNTKVWLRESMERLRRQTSHAPSHLAPTSGPDTVTLNKMEATAKSLF---QLG---- 232
            .:...:|:...|.||                         .|.|...||..:..:   |||
  Fly   176 HMVNYKDFIRAKEWL-------------------------MVGLKMYEADEEIEYIYSQLGMPLV 215

  Fly   233 DFDTAF-----ELSQRVLQFDPKR--IRNWHLGDKGTAPPEDID-DVYLPKHSDSYSLSQEFAK- 288
            ||...|     ||..|.|.....:  |:||         ||.:. ...|.:...:..:.:|.|:
  Fly   216 DFYELFVEIQDELGSRYLAMSELQLAIKNW---------PEKVSLQRALSRLKMNIRIGKEPAEK 271

  Fly   289 -------YEKVCRGEVHPIVRQELRCRYSRGNHPYRFLAPLKLEEHSLDPYVATFHDILSPGKIS 346
                   |:|.|..|..|..:  |.|.|...:..:..|||||:|..|||||:..|||::|...|.
  Fly   272 KNKSKRVYKKCCSSECRPTAK--LYCLYKTTSSYFLRLAPLKMELLSLDPYMVLFHDVVSDKDIV 334

  Fly   347 QLREMAVPRMHRSTVNPLPGGQLKKSAFRVSKNAWLAYESHPTMVGMLRDLKDATGLDTTFCEQL 411
            .:|.:...::.| ||.....|...:...|.:|..||. |::..:..:.:..:|.|..|....:..
  Fly   335 SIRNLTKGKLAR-TVTVSKDGNYTEDPDRTTKGTWLV-ENNALIQRLSQLTQDMTNFDIHDADPF 397

  Fly   412 QVANYGVGGHYEPHWDFFRDPNHYPAEEGN---RIATAIFYLSEVEQGGATAFPFLDIAVKPQLG 473
            ||.|||:||.|..|:||..|     ||..|   |||||:||||:|.|||||.||.|.::|.|:.|
  Fly   398 QVLNYGIGGFYGIHFDFLED-----AELDNFSDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKG 457

  Fly   474 NVLFWYNLHRSLDKDYRTKHAGCPVLKGSKWIGNVWIHEVTQTFARPC 521
            :.|.||||....|.|.||.|:.||.:.||:|:...||:|..|.|.|||
  Fly   458 SALLWYNLDHKGDGDNRTAHSACPTVVGSRWVMTKWINEREQIFRRPC 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	38/142 (27%)
PH4alphaNE1	NP_733374.1	P4Hc	341..511	CDD:214780	67/172 (39%)
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	38/142 (27%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	66/171 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461808
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900