DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE1 and CG18233

DIOPT Version :9

Sequence 1:	NP_733374.1	Gene:	PH4alphaNE1 / 43625	FlyBaseID:	FBgn0039780	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	145/543 - (26%)
Similarity:	249/543 - (45%)	Gaps:	64/543 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLLVGLIFLLAQGSLASD---------YFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLES 60
            |:....:.:|.|...::|         |.||:.||..||..||..........|.:|..:..|..
  Fly     4 VVRAAAVLILVQSIHSTDPNDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNI 68

  Fly    61 ELSSIEKEHTMAASDTENYLTNPVNVYRLMKRLHTDWSLMEGRVQLMAEEMNFNATREYGLSYPS 125
            .|.::::.:....::.|.:::||:|.:.|::||:.||..::...|.........|.::...:.|.
  Fly    69 FLDALKRPNHKTHNEREKFVSNPLNAFGLIRRLNQDWPKLQNYTQKPLGLEQLTAMQDIVSAAPE 133

  Fly   126 QEDVEGAALALVRLQSTYKLDVAQVAQGILNGVKYGSDMSWQDCFELGQQLFEMEDYNNTKVWLR 190
            ..|:.....|:.|:::||.|....:|:|:|...::...:.::||..|....||:.::..:.:|.:
  Fly   134 SFDMNEKLKAMHRIETTYDLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSLLWFQ 198

  Fly   191 E--------SMERLRRQTSHAPSHLAPTSGPDTVTLNKMEATAKSLFQLGDFDTAFELSQRVLQF 247
            |        |:|.:.|.........|......::.|:....|.:::..:.:..........:.|.
  Fly   199 EALKLSTDGSLEIMNRLKEIELKGFATAVAKRSIYLSNQGLTNETIDDMANSQLQDAKLMDLEQL 263

  Fly   248 DPKRIRNWHLGDKGTAPPEDIDDVYLPKHSDSYSLSQEFAKYEKVCRGEVHPIVRQELRCRYSRG 312
            ....::.| :.|..|.||.|            ::|.         ||| :.| .:..|.|||:..
  Fly   264 ISSELKQW-INDDSTTPPTD------------HNLG---------CRG-LFP-KKSNLVCRYNSS 304

  Fly   313 NHPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRSTVNPLPGG--QLKKSAFR 375
            .:.:..|||||:||.|.|||:..||:::|...|.::         :..:..:..|  .|......
  Fly   305 TNAFLKLAPLKMEEISRDPYIVMFHEVISDKDIEEM---------KGEITEMENGWTSLGDPKEI 360

  Fly   376 VSKNAWLAYESHPTMVGMLRDLKDATGLDTTFCEQLQVANYGVGGHYEPHWDFFRDPNHYPAEE- 439
            ||:..|:..||..:. .:.:.:.|.||........:|:||:||||:::||:||:.|    ..:|
  Fly   361 VSRVYWIRKESSFSK-RINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDFYTD----RLKEV 420

  Fly   440 ------GNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSLDKDYRTKHAGCPV 498
                  |:||.:.|||..||.|||.|.||.|.:||:|:.||.|||:|.......|.|:.|:.|||
  Fly   421 DVNNTLGDRIGSIIFYAGEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVCPV 485

  Fly   499 LKGSKWIGNVWIHEVTQTFARPC 521
            |.||:|....|:|...|.|.:||
  Fly   486 LVGSRWTITKWLHYAPQLFVKPC 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	31/128 (24%)
PH4alphaNE1	NP_733374.1	P4Hc	341..511	CDD:214780	60/178 (34%)
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	31/128 (24%)
		ATP-synt_B	<198..278	CDD:304375	10/80 (13%)
		P4Hc	333..498	CDD:214780	60/178 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461763
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	1	0.950	-	0	Normalized mean entropy	S3137
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.850