DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE1 and P4ha3

DIOPT Version :9

Sequence 1:	NP_733374.1	Gene:	PH4alphaNE1 / 43625	FlyBaseID:	FBgn0039780	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_038938408.1	Gene:	P4ha3 / 361612	RGDID:	735150	Length:	549	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	162/540 - (30%)
Similarity:	250/540 - (46%)	Gaps:	81/540 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVGLIFLL-------AQGSLASDYFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSS 64
            |..|:.||       |..:...|.||::|.:...|..|:.|...||..:...:..|:.|......
  Rat     7 LAALLVLLELGVGDPAAAAGREDTFSALTSVARALAPERRLLGTLRRYLRGEEARLRDLTRFYDK 71

  Fly    65 IEKEHTMAASDTENYLTNPVNVYRLMKRLHTDW----SLMEGRVQLMAEEMNFNATREYGLSYPS 125
            :...|    .|.:..:.||:..:.|:|||.:||    ..:|....:.|.:..:....:   ..|:
  Rat    72 VLSLH----EDLKIPVVNPLLAFTLIKRLQSDWRNVVHSLEATENIRALKDGYEKVEQ---DLPA 129

  Fly   126 QEDVEGAALALVRLQSTYKLDVAQVAQGILNGVKYGS-----------DMSWQDCFELGQQLFEM 179
            .||:||||.||:|||..|.|:|..:|||:...|...|           .::..|||::|:..::.
  Rat   130 FEDLEGAARALMRLQDVYMLNVKGLAQGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKVAYDT 194

  Fly   180 EDYNNTKVWLRESMERLRRQTSHAPSHLAPTSGPDTVTL-NKMEATAKSLFQLGDFDTAFELSQR 243
            .||.:...||.|::...||......:.       |..:| :.::..|.:.:|:|:...|..||:.
  Rat   195 GDYYHAIPWLEEAVSLFRRSYGEWKTE-------DEASLEDALDYLAFACYQVGNVSCALSLSRE 252

  Fly   244 VLQFDP--KRI------------RNWHLGDKGTAPPEDIDDVYLPKHSDSYSLSQEFAKYEKVCR 294
            .|.:.|  ||:            .|.||....||    |....:|.       .|....||.:|:
  Rat   253 FLVYSPDNKRMARNVLKYERLLAENGHLMAAETA----IQRPNVPH-------LQTRDTYEGLCQ 306

  Fly   295 --GEVHPIVRQ--ELRCRYSRGNHPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPR 355
              |. .|...|  .|.|.|...:.||..|.|.:.|...|.|.||.:||.:|..:..::||:|.|.
  Rat   307 TLGS-QPTHYQIPSLYCSYETNSSPYLLLQPARKEVIHLRPLVALYHDFVSDEEAQKIRELAEPW 370

  Fly   356 MHRSTVNPLPGGQLKKSAFRVSKNAWLAYESHPTMVGMLRDLKDATGLD--TTFCEQLQVANYGV 418
            :.||.|  ..|.:..:..:|:||:|||.....|.:|.:.|.:...||||  ..:.|.|||.|||:
  Rat   371 LQRSVV--ASGEKQLQVEYRISKSAWLKDTVDPVLVTLDRRIAALTGLDIQPPYAEYLQVVNYGI 433

  Fly   419 GGHYEPHWDFFRDPNH--YPAEEGNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFW-YN 480
            |||||||:|....|:.  |..:.|||:||.:.|||.||.||||||.:.:.:|.     |:.| .:
  Rat   434 GGHYEPHFDHATSPSSPLYKMKSGNRVATLMIYLSSVEAGGATAFIYGNFSVP-----VVKWPTS 493

  Fly   481 LHRSLDKDYRTKHAGCPVLK 500
            .:.|:|::  ::....|:||
  Rat   494 GYTSMDRN--SEDPAAPILK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	38/132 (29%)
PH4alphaNE1	NP_733374.1	P4Hc	341..511	CDD:214780	63/165 (38%)
P4ha3	XP_038938408.1	P4Ha_N	34..108	CDD:400573	18/77 (23%)
P4ha3	XP_038938408.1	P4Hc	356..>478	CDD:214780	53/123 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343156
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860