Protein Alignment PH4alphaNE1 and P4ha2

DIOPT Version :10

• Sequence 1: NP_733374.1
• Gene: PH4alphaNE1 / 43625
• FlyBaseID: FBgn0039780
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001101745.1
• Gene: P4ha2 / 360526
• RGDID: 1309673
• Length: 535
• Species: Rattus norvegicus
• Alignment Length: 556
• Identity: 198/556 - (35%)
• Similarity: 307/556 - (55%)
• Gaps: 70/556 - (12%)

  Fly     4 LVLLVGLIFLLAQGSLASDYFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSSIEKE 68
            ||||:....:|:.  :.:::|:||..:.||::.|:.|.:.|:..:.|.:..|.:::|..|.:|..
  Rat     6 LVLLMSWFGVLSW--VQAEFFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEAL 68

  Fly    69 HTMAASDTENYLTNPVNVYRLMKRLHTDWS------LMEGRVQLMAEEMNFNATREYGLSYPSQE 127
            .:.:|:|.|.||.:|||.|:|:|||:|||.      |.:.....:|   |.:..|::   :|:.|
  Rat    69 TSKSAADPEGYLAHPVNAYKLVKRLNTDWPALGDLVLQDAAAGFVA---NLSVQRQF---FPTDE 127

  Fly   128 DVEGAALALVRLQSTYKLDVAQVAQGILNGVKYGSDMSWQDCFELGQQLFEMEDYNNTKVWLRES 192
            |..|||.||:|||.|||||...:::|.|.|.||.:.:|..|||.:|:..:...||.:|.:|:.:.
  Rat   128 DESGAARALMRLQDTYKLDPDMISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQV 192

  Fly   193 MERLRRQTSHAPSHLAPTSGPDTVTLNK---MEATAKSLFQLGDFDTAFELSQRVLQFDP----- 249
            :::|              ...:..|:.|   ::..:.::|||||...|.||::|:|..||
  Rat   193 LKQL--------------DAGEEATVTKSLVLDYLSYAVFQLGDLHRAVELTRRLLSLDPSHERA 243

  Fly   250 -------KRIRNWHLG-------DKGTAPPEDIDD---VYLPKHSDSYSLSQEFAKYEKVCRGE- 296
                   :|:.....|       |.|.|..|::.:   .|||:..          .||.:||||
  Rat   244 GGNLRYFERLLEEERGKSLSNQTDAGLASQENLYERPVDYLPERD----------VYESLCRGEG 298

  Fly   297 --VHPIVRQELRCRYSRGNH-PYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHR 358
              :.|..::.|.|||..||. |...:||.|.|:....|::..::|::|..:|.:::|:|.|::.|
  Rat   299 IKMTPRRQKRLFCRYHHGNRVPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLAR 363

  Fly   359 STVNPLPGGQLKKSAFRVSKNAWLAYESHPTMVGMLRDLKDATGLDTTFCEQLQVANYGVGGHYE 423
            :||.....|.|..:::||||::||..:..|.:..:.|.::..|||.....|.|||||||:||.||
  Rat   364 ATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYE 428

  Fly   424 PHWDFFRDPNHYPAEE---GNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSL 485
            ||:||.|.......:.   |||:||.:.|:|:||.||||.||.|..|:.|:.|..:|||||.||.
  Rat   429 PHFDFSRSDERDAFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSG 493

  Fly   486 DKDYRTKHAGCPVLKGSKWIGNVWIHEVTQTFARPC 521
            :.||||:||.||||.|.||:.|.|.||..|.|.|||
  Rat   494 EGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..157	CDD:462433	50/136 (37%)
		P4Hc	341..511	CDD:214780	79/172 (46%)
P4ha2	NP_001101745.1	P4Ha_N	26..157	CDD:462433	50/136 (37%)
		P4Hc	346..519	CDD:214780	79/172 (46%)