DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE1 and CG31016

DIOPT Version :9

Sequence 1:	NP_733374.1	Gene:	PH4alphaNE1 / 43625	FlyBaseID:	FBgn0039780	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	173/553 - (31%)
Similarity:	269/553 - (48%)	Gaps:	75/553 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLLVGLIFLLAQGSLA------SDYFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELS 63
            |:|..:.|:|....:|      .:|..|:....|||..:    |||...:::..|.|.:....|.
  Fly     4 VVLFAVSFILVLSWIAEGYRDRQNYVISVEEKMDLLEKD----RELIIVLDSYATELNEKIIMLK 64

  Fly    64 SIEKEHTM----AASDTENYLTNPVNVYRLMKRLHTDWSLME-------GRVQL-MAEEMNFNAT 116
            .|.||...    |.:..|.||:||::...||:::|.||..:|       |:.:: :.|:|
  Fly    65 RIVKEFKQPLEKAKNREEEYLSNPIDSLSLMRQMHEDWEKVEKLLKKPVGQEKIALVEKM----- 124

  Fly   117 REYGLSYPSQEDVEGAALALVRLQSTYKLDVAQVAQGILNGVKYGSDMSWQDCFELGQQLFEMED 181
            ||   ..|.:.|:..|..|:.|:..||.|:...|:.|.::||:||..||..|||.:|...|....
  Fly   125 RE---DLPVENDLMEANQAMFRILHTYDLEPKDVSAGWIDGVQYGGKMSASDCFTMGTFSFMAGS 186

  Fly   182 YNNTKVWLRESMERLRRQTSHAPSHLAPTSGPDTVTLNKMEAT---AKSLFQLGDFDTAFELSQR 243
            |.....||..:.:.|..|         |....:.:.:.|.:.|   |:||...|:...|.::..|
  Fly   187 YQIASKWLSAAKDLLVDQ---------PRKYHEVMGITKADVTLLLARSLIASGNVSIATDMLMR 242

  Fly   244 VLQFDPKRIRNWHLGDKGTAPPEDIDDVYL---PKHSDSYSLSQEFAKYEKVCR-------GEVH 298
            ...|          |:.|:|    :...:|   ||.|.:....:....:.::||       ||..
  Fly   243 DFMF----------GEAGSA----LTVHFLRNKPKPSINLESWESDESFNQLCRSSSRRQMGESK 293

  Fly   299 PIVRQELRCRYSRGNHPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRSTVNP 363
            |   ..|.|||:....|:..|||.::||.||||||..:|::||..:|.:|:.|..|.:.|:.|..
  Fly   294 P---SRLHCRYNTITTPFLKLAPFRMEELSLDPYVIFYHNVLSDAEIEKLKPMGKPFLERAKVFR 355

  Fly   364 LPGGQLKKSAFRVSKNAWLAYES-HPTMVGML----RDLKDATGLDTTFCEQLQVANYGVGGHYE 423
            :..|..:....|.:..|||.::: .|..:.:|    |.::|.|||:|....::|...||.|||:.
  Fly   356 VEKGSDEIDPSRSADGAWLPHQNIDPDDLEVLNRIGRRIEDMTGLNTRSGSKMQFLKYGFGGHFV 420

  Fly   424 PHWDFFRDPNHYPAEEGNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHR-SLDK 487
            ||:|:|..........|:||||.:|||:.|:.||||.||.|::||..|.|:.|||:|:.| |.|.
  Fly   421 PHYDYFNSKTFSLETVGDRIATVLFYLNNVDHGGATVFPKLNLAVPTQKGSALFWHNIDRKSYDY 485

  Fly   488 DYRTKHAGCPVLKGSKWIGNVWIHEVTQTFARP 520
            |.||.|..||::.|:|.:...||:|:.|.|..|
  Fly   486 DTRTFHGACPLISGTKLVMTRWIYELDQMFLIP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	40/140 (29%)
PH4alphaNE1	NP_733374.1	P4Hc	341..511	CDD:214780	66/175 (38%)
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	40/140 (29%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	65/174 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461919
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900