Protein Alignment PH4alphaNE1 and P4ha3

DIOPT Version :10

• Sequence 1: NP_733374.1
• Gene: PH4alphaNE1 / 43625
• FlyBaseID: FBgn0039780
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: XP_006508007.1
• Gene: P4ha3 / 320452
• MGIID: 2444049
• Length: 551
• Species: Mus musculus
• Alignment Length: 583
• Identity: 173/583 - (29%)
• Similarity: 260/583 - (44%)
• Gaps: 113/583 - (19%)

  Fly     8 VGLIFLLAQG------SLASDYFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSSIE 66
            :.|:.|||.|      :...|.||::|.:...|..|:.|...||..:...:..|:.|......:.
Mouse     7 LALLALLALGGDPAAATGREDTFSALTSVARALAPERRLLGTLRRYLRGEEARLRDLTRFYDKVL 71

  Fly    67 KEHTMAASDTENYLTNPVNVYRLMKRLHTDW----SLMEGRVQLMAEEMNFNATREYGLSYPSQE 127
            ..|    .|.:..:.||:..:.|:|||.:||    ..:|....:.|.:..:....:   ..|:.|
Mouse    72 SLH----EDLKIPVVNPLLAFTLIKRLQSDWRNVVHSLEATENIRALKDGYEKVEQ---DLPAFE 129

  Fly   128 DVEGAALALVRLQSTYKLDVAQVAQGILNGVKYGS-----------DMSWQDCFELG-------- 173
            |:||||.||:|||..|.|:|..:|:|:...|...|           .::..|||::|
Mouse   130 DLEGAARALMRLQDVYMLNVKGLARGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKPSCGSRS 194

  Fly   174 -QQLFEMEDYNNTKVWLRESMERLRRQTSHAPSHLAPTSGPDTVTL-NKMEATAKSLFQLGDFDT 236
             |..::..||.:...||.|::...||......:.       |..:| :.::..|.:.||:|:...
Mouse   195 LQVAYDTGDYYHAIPWLEEAVSLFRRAHGEWKTE-------DEASLEDALDYLAFACFQVGNVSC 252

  Fly   237 AFELSQRVLQFDPKRIRNWHLGDKGTAPPEDIDDVYLPKHSDSYSLSQEFAKYEKVCRGEVHPIV 301
            |..||:..|.:.|                            |:..:::...|||::.....|.:.
Mouse   253 ALSLSREFLVYSP----------------------------DNKRMARNVLKYERLLAENGHQMA 289

  Fly   302 RQ----------------------------------ELRCRYSRGNHPYRFLAPLKLEEHSLDPY 332
            .:                                  .|.|.|...:.||..|.|.:.|...|.|.
Mouse   290 AETAIQRPNVPHLQTRDTYEGLCQTLGSQPTHYQIPSLYCSYETNSSPYLLLQPARKEVVHLRPL 354

  Fly   333 VATFHDILSPGKISQLREMAVPRMHRSTVNPLPGGQLKKSAFRVSKNAWLAYESHPTMVGMLRDL 397
            :|.:||.:|..:..::||:|.|.:.||.|  ..|.:..:..:|:||:|||.....|.:|.:...:
Mouse   355 IALYHDFVSDEEAQKIRELAEPWLQRSVV--ASGEKQLQVEYRISKSAWLKDTVDPMLVTLDHRI 417

  Fly   398 KDATGLD--TTFCEQLQVANYGVGGHYEPHWDFFRDPNH--YPAEEGNRIATAIFYLSEVEQGGA 458
            ...||||  ..:.|.|||.|||:|||||||:|....|:.  |..:.|||:||.:.|||.||.|||
Mouse   418 AALTGLDIQPPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMKSGNRVATFMIYLSSVEAGGA 482

  Fly   459 TAFPFLDIAVKPQLGNVLFWYNLHRSLDKDYRTKHAGCPVLKGSKWIGNVWIHEVTQTFARPC 521
            |||.:.:.:|.......|||:|||||.:.|..|.|||||||.|.||:.|.||||..|.|.|||
Mouse   483 TAFIYGNFSVPVVKNAALFWWNLHRSGEGDGDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPC 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..157	CDD:462433	37/134 (28%)
		P4Hc	341..511	CDD:214780	77/173 (45%)
P4ha3	XP_006508007.1	P4Ha_N	31..158	CDD:462433	37/133 (28%)
		P4Hc	363..535	CDD:214780	77/173 (45%)