DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE1 and CG31524

DIOPT Version :9

Sequence 1:	NP_733374.1	Gene:	PH4alphaNE1 / 43625	FlyBaseID:	FBgn0039780	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_733379.2	Gene:	CG31524 / 318781	FlyBaseID:	FBgn0051524	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	164/551 - (29%)
Similarity:	261/551 - (47%)	Gaps:	72/551 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLLVGLIFL-LAQGSLASD---YFSSITGLEDLLHTEQYLTRELRS-------KVNAIQTALQQL 58
            :|.|.:.|| |:.|.:.:.   :..|:..::|||:.|..|..:|..       |.|.|:..:||:
  Fly     6 LLFVVIFFLSLSMGQIEATQPRFARSVVNMDDLLNMEDDLVSKLEGYAEKLSYKANTIRWGIQQM 70

  Fly    59 ESELSSIEKEHTMAASDTENYLTNPVNVYRLMKRLHTDWSLMEGRVQ--LMAEEMNFNATREYGL 121
            ..:|...:||.:.          :..|.|..::.:..||.:.:..:.  ::.:|:|:.  :...|
  Fly    71 REQLDKSKKEQSF----------DLFNRYSFIRHMQADWLMWKQYLDKPVIRDELNYK--QMDNL 123

  Fly   122 SYPSQEDVEGAALALVRLQSTYKLDVAQVAQGILNGVKYGSDMSWQDCFELGQQLFEMEDYNNTK 186
            ..|.:.|:..|:.|:.|:|:||.:....:|:|.|:||:|.|.:|..||..:|:.|.....:...:
  Fly   124 RMPQELDLFDASEAIRRMQATYAMLSNDIAEGFLDGVQYTSKLSPIDCLAMGRHLMNQSRWTIAE 188

  Fly   187 VWLRESMERLRRQTSHAPSHL--APTSGPDTVTLNKM------EATAKSLFQ---------LGDF 234
            .|:...::...|:.......|  .||......||.|:      |..|...:|         |..|
  Fly   189 QWILAGIKAQDRKGPQTEMILLRGPTKAELFRTLGKVRFERRNEEGALKAYQAALKHSPHDLEIF 253

  Fly   235 DTAFELSQRVLQFDPKR-IRNWHLGDKGTAPPEDIDDVYLPKHSDSYSLSQEFAKYEKVCRGEVH 298
            .....|.:|||...|.. ||.        .|.:||:::.||                ..|.|...
  Fly   254 QEYQNLKRRVLTLSPSEPIRE--------EPNDDIEEMELP----------------PCCSGRCE 294

  Fly   299 -PIVRQELRCRYSRGNHPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRS-TV 361
             |.....|.|.|:....|:..|||:|.|..|:||:|...||::|..:.:.:|..:..::..| ||
  Fly   295 GPRKLNRLYCVYNCVTAPFLRLAPIKTEILSVDPFVILLHDMVSHKEGALIRSSSKNQILPSETV 359

  Fly   362 NPLPGGQLKKSAFRVSKNAWLAYESHPTMVGMLRDLKDATGLDTTFCEQLQVANYGVGGHYEPHW 426
            |  ...:.:.:.||.||:.|...:::...:.:.:.|.:|||||....|..||.|||:||.:|.|:
  Fly   360 N--AANEFEIAKFRTSKSVWFDSDANEATLKLTQRLGEATGLDMKHSEPFQVINYGIGGVFESHF 422

  Fly   427 D-FFRDPNHYPAEEGNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSLDKDYR 490
            | ...|.:.:.....:|:||.:|||::|.|||||.||.|:|.|.|:.|.||.|||||.......|
  Fly   423 DTSLADEDRFVNGYIDRLATTLFYLNDVPQGGATHFPGLNITVFPKFGTVLMWYNLHTEGMLHVR 487

  Fly   491 TKHAGCPVLKGSKWIGNVWIHEVTQTFARPC 521
            |.|.||||:.||||:.:.||.:..|.|.|||
  Fly   488 TMHTGCPVIVGSKWVVSKWIDDKGQEFRRPC 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	32/137 (23%)
PH4alphaNE1	NP_733374.1	P4Hc	341..511	CDD:214780	67/171 (39%)
CG31524	NP_733379.2	P4Ha_N	31..157	CDD:285528	32/137 (23%)
		TPR_11	215..>259	CDD:290150	8/43 (19%)
		TPR_2	216..249	CDD:285020	6/32 (19%)
		P4Hc	340..507	CDD:214780	65/168 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461811
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900