DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE1 and CG32201

DIOPT Version :9

Sequence 1:	NP_733374.1	Gene:	PH4alphaNE1 / 43625	FlyBaseID:	FBgn0039780	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	164/561 - (29%)
Similarity:	267/561 - (47%)	Gaps:	93/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LVLLVGLIFLLAQGSLASD------YFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESEL 62
            |.:|:|...|.:......|      |.||..||..||..|:..|..|.::|:.:....:.|...|
  Fly     8 LPVLLGFAVLNSFVGCVEDIEEKERYSSSTVGLLKLLKVEEKFTDNLLNQVDQLGEKFEALRMYL 72

  Fly    63 SSIEKEHTMAASDTENYLTNPVNVYRLMKRLHTD---W------SLMEGRVQLMAEEMNFNATRE 118
            ||:..|...:.::...|::||:|.:.|::|.|.|   |      ::.||...::.:.:..
  Fly    73 SSVGYELHRSLNEKVQYVSNPINAFSLLRRTHEDLPKWHEYFKEAIGEGNQSILVDLVKM----- 132

  Fly   119 YGLSYPSQEDVEGAALALVRLQSTYKLDVAQVAQGILNGVKYGSDMSWQDCFELGQQLFEMEDYN 183
                .|:..|:..|...:.|::..|.|.:..:|||:|.||:|...::::|...:|..:::..||.
  Fly   133 ----VPNDVDMLSAMHGIQRIEKIYDLKIDDLAQGVLQGVQYNVQLTYRDLIAMGNSMYQQSDYQ 193

  Fly   184 NTKVWLR-------ESMERLRRQTSHAPS-HLAPTSGPDTVTLNKMEATAKSLFQLGDFDTAFEL 240
            ....|.|       |:.|:|..|....|| ||             .....||||:.|  .|..|.
  Fly   194 TAAKWYRIACKRELENPEQLFIQILGDPSEHL-------------HRQYIKSLFKYG--STTSEP 243

  Fly   241 SQRV------LQFDPKRIRNWHLGDKGTAPPEDID---DVYLPKHSDSYSLSQEFAKYEKVCRGE 296
            |:.:      :|...:.:.|  :......|..|::   |:|..|.|.|        ..|..|||
  Fly   244 SKSIEEAFIMVQASQEELDN--IMSDLNEPQNDVEVEKDLYQVKRSPS--------NCELGCRG- 297

  Fly   297 VHPIVRQE--LRCRYSRGNHPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRS 359
               :.||:  |.|||....:.:..||||||||.||||::|.:|::|...:|.:|:..:: .|...
  Fly   298 ---LYRQKTNLVCRYKSTANTFLRLAPLKLEEISLDPFMAMYHEVLYDSEIRELKGQSM-NMVNG 358

  Fly   360 TVNPLPGGQLKKSAFRVSKNAWLAYESHPTMVGMLRD-----LKDATGLDTTFCEQLQVANYGVG 419
            ..:...|.:::.:..|..   |.:..|      ::|:     :.|.||.:....|:||:||||:|
  Fly   359 YASQRNGTEIRDTVVRYD---WWSNTS------LVRERINQRIIDMTGFNFLKDEKLQIANYGLG 414

  Fly   420 GHYEPHWDF----FRDPNHYPAEEGNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYN 480
            .:::||:|:    |..||  ....|:|:|:.:||.|||.|||||.||.:::.|.||.|::|:|:|
  Fly   415 TYFQPHFDYSSDGFETPN--ITTLGDRLASILFYASEVPQGGATVFPEINVTVFPQKGSMLYWFN 477

  Fly   481 LHRSLDKDYRTKHAGCPVLKGSKWIGNVWIHEVTQTFARPC 521
            ||.....|.|:.|:.||||.|.:|....|:....|.|:.||
  Fly   478 LHDDGKPDIRSLHSVCPVLNGDRWTLTKWVPMFPQMFSFPC 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	34/137 (25%)
PH4alphaNE1	NP_733374.1	P4Hc	341..511	CDD:214780	59/178 (33%)
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	34/137 (25%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	58/177 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461759
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900