Protein Alignment PH4alphaNE1 and P4HA3

DIOPT Version :9

• Sequence 1: NP_733374.1
• Gene: PH4alphaNE1 / 43625
• FlyBaseID: FBgn0039780
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001275677.1
• Gene: P4HA3 / 283208
• HGNCID: 30135
• Length: 604
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 159/561 - (28%)
• Similarity: 263/561 - (46%)
• Gaps: 93/561 - (16%)

  Fly     7 LVGLIFLLAQG-------SLASDYFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSS 64
            |..|:.:||.|       :...|.||::|.:...|..|:.|...||..:...:..|:.|......
Human     7 LAALLAVLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYDK 71

  Fly    65 IEKEHTMAASDTENYLTNPVNVYRLMKRLHTDWSLMEGRVQLMAEEMNFNATREYGLSY------ 123
            :...|    .|:...:.||:..:.|:|||.:||   ...|..:....|..|.::   .|
Human    72 VLSLH----EDSTTPVANPLLAFTLIKRLQSDW---RNVVHSLEASENIRALKD---GYEKVEQD 126

  Fly   124 -PSQEDVEGAALALVRLQSTYKLDVAQVAQGILNGVKYGS------------DMSWQDCFELGQQ 175
             |:.||:||||.||:|||..|.|:|..:|:|:...|. ||            .::..|||::|:.
Human   127 LPAFEDLEGAARALMRLQDVYMLNVKGLARGVFQRVT-GSAITDLYSPKRLFSLTGDDCFQVGKV 190

  Fly   176 LFEMEDYNNTKVWLRESMERLRRQTSHAPSHLAPTSGPDTVTL-NKMEATAKSLFQLGDFDTAFE 239
            .::|.||.:...||.|::...|.......:.       |..:| :.::..|.:.|:.|:...|..
Human   191 AYDMGDYYHAIPWLEEAVSLFRGSYGEWKTE-------DEASLEDALDHLAFAYFRAGNVSCALS 248

  Fly   240 LSQRVLQFDP--KRI-RNWHLGDK--GTAPPEDIDDVYLPKHSDSYSLSQEFAKYEKVCR--GEV 297
            ||:..|.:.|  ||: ||....::  ..:|...:.:..:.:.:..:..:::  .||.:|:  |.
Human   249 LSREFLLYSPDNKRMARNVLKYERLLAESPNHVVAEAVIQRPNIPHLQTRD--TYEGLCQTLGS- 310

  Fly   298 HPIVRQ--ELRCRYSRGNHPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRST 360
            .|.:.|  .|.|.|...::.|..|.|::.|...|:||:|.:||.:|..:..::||:|.|.:.||.
Human   311 QPTLYQIPSLYCSYETNSNAYLLLQPIRKEVIHLEPYIALYHDFVSDSEAQKIRELAEPWLQRSV 375

  Fly   361 VNPLPGGQLKKSAFRVSKNAWLAYESHPTMVGMLRDLKDATGLDT--TFCEQLQVANYGVGGHYE 423
            |  ..|.:..:..:|:||:|||.....|.:|.:...:...||||.  .:.|.|||.|||:|||||
Human   376 V--ASGEKQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRPPYAEYLQVVNYGIGGHYE 438

  Fly   424 PHWDFFRDPNH--YPAEEGNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGN------------ 474
            ||:|....|:.  |..:.|||:||.:.|||.||.||||||.:.:::| |.:.:
Human   439 PHFDHATSPSSPLYRMKSGNRVATFMIYLSSVEAGGATAFIYANLSV-PVVRHCFGGTCTGVVKG 502

  Fly   475 --------VLFWYNL-------HRSLDKDYRTKHAGCPVLK 500
                    ||.|:.:       :.|:|::  :.....|.||
Human   503 TVTHFMLAVLSWWEISGWPTSGYMSMDRN--SADPAAPALK 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	39/135 (29%)
		P4Hc	341..511	CDD:214780	64/191 (34%)
P4HA3	NP_001275677.1	P4Ha_N	58..159	CDD:285528	33/110 (30%)
		TPR_12	186..252	CDD:290160	16/72 (22%)
		P4Hc	356..>478	CDD:214780	52/123 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860