Protein Alignment PH4alphaNE1 and P4ha1

DIOPT Version :9

• Sequence 1: NP_733374.1
• Gene: PH4alphaNE1 / 43625
• FlyBaseID: FBgn0039780
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_001303300.1
• Gene: P4ha1 / 18451
• MGIID: 97463
• Length: 534
• Species: Mus musculus
• Alignment Length: 556
• Identity: 205/556 - (36%)
• Similarity: 317/556 - (57%)
• Gaps: 69/556 - (12%)

  Fly     4 LVLLVGLIFLLAQGSLASDYFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSSIEKE 68
            :||::.:  ||.|......:|:||..:.||:|.|:.|...|:..:.|.:..|:|::.....:::.
Mouse     4 VVLMMAI--LLPQSLAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRL 66

  Fly    69 HTMAASDTENYLTNPVNVYRLMKRLHTDWSLMEGRVQLMAEEM------NFNATREYGLSYPSQE 127
            .:.|..|.|.::.:|||.::|||||:|:||.:|   .|:.::|      |....|:|   :|:.|
Mouse    67 TSTATKDPEGFVGHPVNAFKLMKRLNTEWSELE---NLILKDMSDGFISNLTIQRQY---FPNDE 125

  Fly   128 DVEGAALALVRLQSTYKLDVAQVAQGILNGVKYGSDMSWQDCFELGQQLFEMEDYNNTKVWLRES 192
            |..|||.||.|||.||.||...:::|.|.||::.|.::.:||||||:..:...||.:|::|:.::
Mouse   126 DQVGAAKALFRLQDTYNLDTNTISKGNLPGVQHKSFLTAEDCFELGKVAYTEADYYHTELWMEQA 190

  Fly   193 MERLRRQTSHAPSHLAPTSGPDTVTLNKMEATAKSLFQLGDFDTAFELSQRVLQFDPKRIR-NWH 256
            :.:|..         ...|..|.|::  ::..:.:::|.||.|.|..|::::|:.||:..| |.:
Mouse   191 LTQLEE---------GELSTVDKVSV--LDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGN 244

  Fly   257 L---------------------GDKGTAPPED---IDDVYLPKHSDSYSLSQEFAKYEKVCRGE- 296
            |                     .|:.|||.:.   :|  |||          |..|||.:||||
Mouse   245 LVYFEYIMSKEKDANKSASGDQSDQKTAPKKKGIAVD--YLP----------ERQKYEMLCRGEG 297

  Fly   297 --VHPIVRQELRCRYSRGN-HPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHR 358
              :.|..::.|.|||..|| :|...|||.|.|:....|.:..||||:|..:|..::::|.||:.|
Mouse   298 IKMTPRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSR 362

  Fly   359 STVNPLPGGQLKKSAFRVSKNAWLAYESHPTMVGMLRDLKDATGLDTTFCEQLQVANYGVGGHYE 423
            :||:....|:|..:.:||||:|||:....|.:..:...::|.||||.:..|:||||||||||.||
Mouse   363 ATVHDPETGKLTTAQYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYE 427

  Fly   424 PHWDFFR--DPNHY-PAEEGNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSL 485
            ||:||.|  :|:.: ....||||||.:||:|:|..||||.||.:..:|.|:.|..:|||||..|.
Mouse   428 PHFDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASG 492

  Fly   486 DKDYRTKHAGCPVLKGSKWIGNVWIHEVTQTFARPC 521
            :.||.|:||.||||.|:||:.|.|:||..|.|.|||
Mouse   493 EGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPC 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	47/134 (35%)
		P4Hc	341..511	CDD:214780	81/172 (47%)
P4ha1	NP_001303300.1	P4Ha_N	24..153	CDD:285528	47/134 (35%)
		TPR	205..238		10/34 (29%)
		P4Hc	345..518	CDD:214780	81/172 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3137
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.780