Protein Alignment PH4alphaNE1 and phy-2

DIOPT Version :10

• Sequence 1: NP_733374.1
• Gene: PH4alphaNE1 / 43625
• FlyBaseID: FBgn0039780
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_502317.1
• Gene: phy-2 / 178170
• WormBaseID: WBGene00004025
• Length: 539
• Species: Caenorhabditis elegans
• Alignment Length: 554
• Identity: 189/554 - (34%)
• Similarity: 291/554 - (52%)
• Gaps: 56/554 - (10%)

  Fly     5 VLLVGLIFLLAQGSLASDYFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSSIEKEH 69
            ||||.|:..||.    :|.|::|..|:.:|..|:.:|..:...:.|.:..|..|..........:
 Worm     4 VLLVCLLAGLAH----ADLFTAIADLQHMLGAEKDVTTIIDQYIEAERARLDDLRRYAHEYVHRN 64

  Fly    70 TMAASDTENYLTNPVNVYRLMKRLHTDWS-----LMEGRVQLMAEEMNFNATREYGLSYPSQEDV 129
            ..|.|....::|||:|.|.|:|||.|:|.     ::..:.....:.:..|..|. .:.:|.:||:
 Worm    65 AHAESVGPEFVTNPINAYLLIKRLTTEWKKVENIMLNNKASTFLKNITDNRVRS-EVKFPGEEDL 128

  Fly   130 EGAALALVRLQSTYKLDVAQVAQGILNGVKYGSDMSWQDCFELGQQLFEMEDYNNTKVWLRESME 194
            .|||.||:|||.||.||...::.||:.|.|..:.:|..|.||:|:..:..:||.:..:|::.::.
 Worm   129 SGAATALLRLQDTYSLDTLDLSNGIIGGEKVSNKLSGHDTFEVGRSAYNQKDYYHCLMWMQVALV 193

  Fly   195 RLRRQTSHAPSHLAPTSGPDTV-TLNKMEATAKSLFQLGDFDTAFELSQRVLQFDPKRIR----- 253
            ::..:            .|.|: ....:|..|.||:|.|:...|..|::|:.:..|...|
 Worm   194 KIENE------------NPPTIEEWEILEYLAYSLYQQGNVRRALSLTKRLAKIAPNHPRAKGNV 246

  Fly   254 NWH---LGDK---GTAPPEDIDDVYLPKHSDSYSLSQEFAKYEKVCRGEVHPIV---RQELRCRY 309
            .|:   |..|   |..||       :......|....|...||.:||||:.|:.   :.:||| |
 Worm   247 KWYEDMLQGKDMVGDLPP-------IVNKRVEYDGIVERDAYEALCRGEIPPVEPKWKNKLRC-Y 303

  Fly   310 SRGNHPYRFLAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRSTVNPLPGGQLKKSAF 374
            .:.:.|:..|||:|:|....||....|.:::...:|..::|:|.|::.|:||.....|:|:.:.:
 Worm   304 LKRDKPFLKLAPIKVEILRFDPLAVLFKNVIHDSEIEVIKELASPKLKRATVQNSKTGELEHATY 368

  Fly   375 RVSKNAWLAYESHPTMVGMLRDLKDATGLDTTFCEQLQVANYGVGGHYEPHWDFFR--DPNHYPA 437
            |:||:|||..:..|.:..:.|.::|.|.|:....|:|||||||:||||:||:||.|  :.|.:..
 Worm   369 RISKSAWLKGDLDPVIDRVNRRIEDFTNLNQATSEELQVANYGLGGHYDPHFDFARKEEKNAFKT 433

  Fly   438 -EEGNRIATAIFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSLDKDYRTKHAGCPVLKG 501
             ..||||||.:||:|:.|:||||.|..|..||.|...:.||||||.|..:.|.||:||.||||.|
 Worm   434 LNTGNRIATVLFYMSQPERGGATVFNHLGTAVFPSKNDALFWYNLRRDGEGDLRTRHAACPVLLG 498

  Fly   502 SKWIGNVWIHEVTQTFARPCDVFRDHEVSLEYEI 535
            .||:.|.||||..|.|.|||        .||.|:
 Worm   499 VKWVSNKWIHEKGQEFTRPC--------GLEEEV 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE1	NP_733374.1	P4Ha_N	26..157	CDD:462433	40/135 (30%)
		P4Hc	341..511	CDD:214780	78/172 (45%)
phy-2	NP_502317.1	P4Ha_N	21..156	CDD:462433	40/135 (30%)
		P4Hc	335..508	CDD:214780	78/172 (45%)