Protein Alignment PH4alphaMP and P4HA2

DIOPT Version :10

• Sequence 1: NP_524594.2
• Gene: PH4alphaMP / 43624
• FlyBaseID: FBgn0026190
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 202/561 - (36%)
• Similarity: 300/561 - (53%)
• Gaps: 77/561 - (13%)

  Fly     2 LLAKCVLFLVLQVLSC-HGEFFSSTSGLAKLFETEVVLLAELQNYV-------NEINQHA---EA 55
            |....:|.....|||| ..|||:|...:..|...|..|:..|:.|:       ::|...|   ||
Human     3 LWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEA 67

  Fly    56 LQSEIDAIRVEHLNAADGIDDYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMASLKE 120
            |.|:         :|||. :.||.:||||::|:|||::||...|..|..||:        |....
Human    68 LTSK---------SAADA-EGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSA--------AGFIA 114

  Fly   121 NLS-----FPSQDDFVGSAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYAL 180
            |||     ||:.:|.:|:|.||.|||.||:||...::.|.|.|.||...:|..|||.:|:..|..
Human   115 NLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNE 179

  Fly   181 RDYNHTVPWLQQSMQLL--GEQSYGSESASLDFMEAVVEYHREMGAHESALSLVNHVLSIEPDQR 243
            .||.|||.|::|.::.|  ||::..::|..||::...|   .::|....||.|...:||::|...
Human   180 GDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAV---FQLGDLHRALELTRRLLSLDPSHE 241

  Fly   244 ---------SHLLEARQQLEELITD------GDKNGLLHLTARRPGDYHESREFRMYEQVCRGEL 293
                     ..|||  ::.|:.:|:      ....|:.    .||.||...|:  :||.:||||.
Human   242 RAGGNLRYFEQLLE--EEREKTLTNQTEAELATPEGIY----ERPVDYLPERD--VYESLCRGEG 298

  Fly   294 APL-PSKQRNLRCRL----RKSRLGYAPFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKR 353
            ..| |.:|:.|.||.    |..:|..||||.|:....|.:|:.:.|:..::.:.:::.|:|::.|
Human   299 VKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLAR 363

  Fly   354 STVYSLGGNGGSTAAAFRTSQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHY 418
            :||.. ...|..|.|::|.|:.:......:.....::|.:...:||.:..||.|||||||:||.|
Human   364 ATVRD-PKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQY 427

  Fly   419 EPHWDSFPENHIYQEGDLH-----GNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYN 478
            |||:| |..|   .|.|..     |||:||.:.|::||||||.|.||.|...:.|::|:.:||||
Human   428 EPHFD-FSRN---DERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYN 488

  Fly   479 LHPSGDQDFRTKHAACPVLQGSKWIANVWIRERNQDNVRPC 519
            |..||:.|:||:|||||||.|.||::|.|..||.|:.:|||
Human   489 LLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..158	CDD:462433	51/148 (34%)
		P4Hc	336..509	CDD:214780	73/177 (41%)
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	51/148 (34%)
		BamD	159..>272	CDD:443281	34/117 (29%)
		TPR	207..240		11/35 (31%)
		P4Hc	346..519	CDD:214780	73/177 (41%)