DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaMP and p4htmb

DIOPT Version :9

Sequence 1:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_001340234.2	Gene:	p4htmb / 799930	ZFINID:	ZDB-GENE-110131-7	Length:	510	Species:	Danio rerio

Alignment Length:	433	Identity:	104/433 - (24%)
Similarity:	150/433 - (34%)	Gaps:	157/433 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 SASLDFMEAVVEYHREMGA--------------------------HESALSLVN------HVLSI 238
            ||:.||..:....|:..||                          |...:|||:      ..||:
Zfish    89 SANRDFTSSDSSSHKVTGASDAQATADSGFPRNMFLPRIEGIRVGHVQKVSLVSGKVHEMKTLSL 153

  Fly   239 EPDQRSHLLEARQQLEELITDGDKNGLLHLTARRPGDYHESREFRMYEQVCRGELAPLPSKQRNL 303
            :|    .|.|....|.|     ::..::...|:..|        .|..||.      :|..|..|
Zfish   154 KP----LLFEIPDFLSE-----EECAVVVRLAQLKG--------LMESQVM------VPEGQEEL 195

  Fly   304 RCRLRKSRLGYAP---FKLEELHLDPLVVQLHQVI-GSKDSDSLQKTARPRIKRSTVY-----SL 359
                 ..:|..:|   |...:|:.|. .:|.|::: .|:..|.:..|:. .:|.  :|     .|
Zfish   196 -----DQQLNLSPEEIFNFLDLNQDG-QLQPHEILTHSRVRDGIWLTSE-NLKE--IYDGLKADL 251

  Fly   360 GGNGGSTAAAF---RTSQGASFNYSRNAATKLL---SRHVGDFSGLN------------------ 400
            .|||..:...|   |:.....|...|......|   |||...:.|..
Zfish   252 DGNGLLSLEEFGRLRSDAFQRFLLQRGVERSQLVRNSRHTWLYQGQGAHQVLQDLRKRVTLLTRL 316

  Fly   401 ----MDYAEDLQVANYGIGGHYEPHWDSFPENHIYQEGDLHGNRMA--------------TGIYY 447
                ::.:|.|||..|..||||..|.||.|   :|.|......|:|              |.::|
Zfish   317 PSSLVELSEPLQVVRYEQGGHYHAHHDSGP---VYPETACTHTRLAANTTSPFQTSCRYITVLFY 378

  Fly   448 LADVEAGGGTAFPFLP---------------------------LLVTPERGSLLFWYNLHPS--- 482
            |.:|:.||.|.||...                           |.|.|.:|:.:||||....
Zfish   379 LNNVQEGGETTFPVADNRTYEEASLIQNDVDLLDTRKHCDKGNLRVKPVKGTAVFWYNYLSDGRG 443

  Fly   483 --GDQDFRTKHAACPVLQGSKWIANVWIRERNQDNVRPCDLER 523
              |:||..:.|..|.|.||:||:||.||      ||.| |.:|
Zfish   444 WVGEQDEYSLHGGCVVTQGTKWVANNWI------NVDP-DYQR 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	65/251 (26%)
p4htmb	XP_001340234.2	EF-hand_7	204..262	CDD:290234	14/61 (23%)
		EFh	204..262	CDD:298682	14/61 (23%)
		P4Hc	285..471	CDD:214780	50/188 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583463
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740