DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaMP and p4htma

DIOPT Version :9

Sequence 1:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001074160.1	Gene:	p4htma / 791209	ZFINID:	ZDB-GENE-070112-2222	Length:	478	Species:	Danio rerio

Alignment Length:	457	Identity:	109/457 - (23%)
Similarity:	162/457 - (35%)	Gaps:	149/457 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 HLY-----ALRDYNH-TVPWLQQSMQLLGEQSYGSESASLDFMEAVVEYHR--EMGAH---ESAL 229
            |||     ||..|.| .....:|.:.|  |:|.||.       .||...|:  ...||   |.:.
Zfish    52 HLYIINIIALLLYVHYNTGSGEQDVPL--EKSAGSP-------RAVPAEHQTPSSTAHLSPEMSF 107

  Fly   230 SL-------VNHV--LSIEPDQRSH---LLEARQQLEEL---ITDGDKNGLLHLTARRPGDYHES 279
            .|       |.||  :||.|| |:|   .|..:..|.|:   ::..:.|.::.| |:..|..|.|
Zfish   108 QLPRLEGIRVGHVQRVSIVPD-RTHNMRTLSLKPLLFEIPGFLSVEESNVVMQL-AQLKGLTHSS 170

  Fly   280 ------REFRMYEQVCRGELAPLPSKQRNLRCRLRKSRLGYAPFKLEELHLDPLVVQLHQVIG-S 337
                  :|    ||:.:.||                       |.|.:|:.|.| :|..:::. |
Zfish   171 LLTNPDQE----EQLTQDEL-----------------------FSLLDLNQDGL-LQREEILSLS 207

  Fly   338 KDSDSLQKTARPRIKRSTVYSLGGNGGSTAAAFRTSQGASFNYSRNAA-----TKLLSR--HVGD 395
            ..:|....::....|..|......:|..:...|:...|....||..|.     ||:..|  |...
Zfish   208 HSTDGSWLSSYNLRKIHTGLETNPSGVLSLQEFKRVSGGVLRYSGAAQGLDGHTKVRQRSTHTRL 272

  Fly   396 FSGLN----------------------MDYAEDLQVANYGIGGHYEPHWDSFPEN------HIYQ 432
            :.|..                      :|.:|.::|..|..|.....|.||.|.:      |.:.
Zfish   273 YLGEGTHHLLKSVRNRVTRLTRLPSSLVDLSEAMEVVRYEQGVFSHAHHDSSPTHPDNSCTHTHL 337

  Fly   433 EGDLHGN---RMATGIYYLADVEAGGGTAFPFLP---------------------LLVTPERGSL 473
            ..:....   |..|.:.||...::||.|:||...                     |.|.|..|:.
Zfish   338 AANTSNQVACRYLTVLLYLNSADSGGETSFPVADNRTYEEEVLGDLSQQYCDKGNLKVKPVAGTA 402

  Fly   474 LFWYNLHPS------GDQDFRTKHAACPVLQGSKWIANVWIRERNQDNVRPCDLERGQE----IS 528
            |.||| |.|      |:.|..:.|..|.|.:|.||..:||:      |:.| |.:|.:.    :|
Zfish   403 LLWYN-HLSDGNGWVGELDEFSLHGDCLVTRGFKWTGSVWV------NIDP-DQQRQERYQRLVS 459

  Fly   529 LH 530
            .|
Zfish   460 WH 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	54/238 (23%)
p4htma	NP_001074160.1	2OG-FeII_Oxy	<272..442	CDD:304390	39/170 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740