DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaMP and P4ha1

DIOPT Version :9

Sequence 1:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_742059.2	Gene:	P4ha1 / 64475	RGDID:	621000	Length:	534	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	178/544 - (32%)
Similarity:	296/544 - (54%)	Gaps:	37/544 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLAKCVLFLVLQVLSCHGEFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEIDAIRV 65
            |:....::.::|...|.|..||:|...:..|...|..|:..|::|:.......|.::...:.:..
  Rat     1 MIWGVLMMGILLPQCSAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDR 65

  Fly    66 EHLNAADGIDDYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMASLKENLSFPSQDDF 130
            ....|....:.::.:|||||:|:|||:::|...|..:..|.| ..::..:...::  .||:.:|.
  Rat    66 LTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMS-DGFISNLTIQRQ--YFPNDEDQ 127

  Fly   131 VGSAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYNHTVPWLQQSMQ 195
            ||:|.||.|||.||.||...::.|.|.|||:.:.::.:|||.||:..|...||.||..|::|::.
  Rat   128 VGAAKALFRLQDTYNLDTNTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALM 192

  Fly   196 LL--GEQSYGSESASLDFMEAVVEYHREMGAHESALSLVNHVLSIEPD-QRSH-------LLEAR 250
            .|  ||.|...:.:.||::...|   .:.|..:.||.|...:|.::|: ||::       .:.::
  Rat   193 QLEEGEMSTVDKVSVLDYLSYAV---YQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIMSK 254

  Fly   251 QQLEELITDGDKNGLLHLTARRPG---DYHESREFRMYEQVCRGE-LAPLPSKQRNLRCRL---- 307
            ::.......||::. ...|.::.|   ||...|:  .||.:|||| :...|.:|:.|.||.
  Rat   255 EKDANKSASGDQSD-QKTTPKKKGIAVDYLPERQ--KYEMLCRGEGIKMTPRRQKRLFCRYHDGN 316

  Fly   308 RKSRLGYAPFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGGNGGSTAAAFRT 372
            |..:...||.|.|:....|.:::.|.:|...:.:.::..|:||:.|:||:. ...|..|.|.:|.
  Rat   317 RNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHD-PETGKLTTAQYRV 380

  Fly   373 SQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWDSFPENHIYQEGDLH 437
            |:.|..:...:.....::..:.|.:||::..||:|||||||:||.||||:|...::    |.|..
  Rat   381 SKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKD----EPDAF 441

  Fly   438 -----GNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRTKHAACPVL 497
                 |||:||.::|::||.|||.|.||.:...|.|::|:.:|||||..||:.|:.|:|||||||
  Rat   442 RELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVL 506

  Fly   498 QGSKWIANVWIRERNQDNVRPCDL 521
            .|:||::|.|:.||.|:..|||.|
  Rat   507 VGNKWVSNKWLHERGQEFRRPCTL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	37/131 (28%)
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	71/177 (40%)
P4ha1	NP_742059.2	P4Ha_N	25..112	CDD:400573	20/87 (23%)
		TPR	205..238		9/35 (26%)
		P4Hc	345..518	CDD:214780	71/177 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930