Protein Alignment PH4alphaMP and P4ha1

DIOPT Version :10

• Sequence 1: NP_524594.2
• Gene: PH4alphaMP / 43624
• FlyBaseID: FBgn0026190
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_742059.2
• Gene: P4ha1 / 64475
• RGDID: 621000
• Length: 534
• Species: Rattus norvegicus
• Alignment Length: 544
• Identity: 178/544 - (32%)
• Similarity: 296/544 - (54%)
• Gaps: 37/544 - (6%)

  Fly     1 MLLAKCVLFLVLQVLSCHGEFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEIDAIRV 65
            |:....::.::|...|.|..||:|...:..|...|..|:..|::|:.......|.::...:.:..
  Rat     1 MIWGVLMMGILLPQCSAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDR 65

  Fly    66 EHLNAADGIDDYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMASLKENLSFPSQDDF 130
            ....|....:.::.:|||||:|:|||:::|...|..:..|.| ..::..:...::  .||:.:|.
  Rat    66 LTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMS-DGFISNLTIQRQ--YFPNDEDQ 127

  Fly   131 VGSAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYNHTVPWLQQSMQ 195
            ||:|.||.|||.||.||...::.|.|.|||:.:.::.:|||.||:..|...||.||..|::|::.
  Rat   128 VGAAKALFRLQDTYNLDTNTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALM 192

  Fly   196 LL--GEQSYGSESASLDFMEAVVEYHREMGAHESALSLVNHVLSIEPD-QRSH-------LLEAR 250
            .|  ||.|...:.:.||::...|   .:.|..:.||.|...:|.::|: ||::       .:.::
  Rat   193 QLEEGEMSTVDKVSVLDYLSYAV---YQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIMSK 254

  Fly   251 QQLEELITDGDKNGLLHLTARRPG---DYHESREFRMYEQVCRGE-LAPLPSKQRNLRCRL---- 307
            ::.......||::. ...|.::.|   ||...|:  .||.:|||| :...|.:|:.|.||.
  Rat   255 EKDANKSASGDQSD-QKTTPKKKGIAVDYLPERQ--KYEMLCRGEGIKMTPRRQKRLFCRYHDGN 316

  Fly   308 RKSRLGYAPFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGGNGGSTAAAFRT 372
            |..:...||.|.|:....|.:::.|.:|...:.:.::..|:||:.|:||:. ...|..|.|.:|.
  Rat   317 RNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHD-PETGKLTTAQYRV 380

  Fly   373 SQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWDSFPENHIYQEGDLH 437
            |:.|..:...:.....::..:.|.:||::..||:|||||||:||.||||:|...::    |.|..
  Rat   381 SKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKD----EPDAF 441

  Fly   438 -----GNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRTKHAACPVL 497
                 |||:||.::|::||.|||.|.||.:...|.|::|:.:|||||..||:.|:.|:|||||||
  Rat   442 RELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVL 506

  Fly   498 QGSKWIANVWIRERNQDNVRPCDL 521
            .|:||::|.|:.||.|:..|||.|
  Rat   507 VGNKWVSNKWLHERGQEFRRPCTL 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..158	CDD:462433	38/133 (29%)
		P4Hc	336..509	CDD:214780	71/177 (40%)
P4ha1	NP_742059.2	P4Ha_N	24..155	CDD:462433	38/133 (29%)
		TPR	205..238		9/35 (26%)
		P4Hc	345..518	CDD:214780	71/177 (40%)