Protein Alignment PH4alphaMP and P4HA1

DIOPT Version :9

• Sequence 1: NP_524594.2
• Gene: PH4alphaMP / 43624
• FlyBaseID: FBgn0026190
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_000908.2
• Gene: P4HA1 / 5033
• HGNCID: 8546
• Length: 534
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 178/539 - (33%)
• Similarity: 294/539 - (54%)
• Gaps: 39/539 - (7%)

  Fly     7 VLFLVLQVLSCHGEFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEIDAIRVEHLNAA 71
            ::.::|.....|..||:|...:..|..||..|:..|::|:.......|.::...:.:......|.
Human     7 IIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTAT 71

  Fly    72 DGIDDYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMASLKENLSFPSQDDFVGSAIA 136
            ...:.::.:|||||:|:|||:::|...|..|..|.| ..::..:...::  .||:.:|.||:|.|
Human    72 KDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMS-DGFISNLTIQRQ--YFPNDEDQVGAAKA 133

  Fly   137 LTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYNHTVPWLQQSMQLL--GE 199
            |.|||.||.||...::.|.|.|||:.:.::.:|||.||:..|...||.||..|::|:::.|  ||
Human   134 LLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGE 198

  Fly   200 QSYGSESASLDFMEAVVEYHREMGAHESALSLVNHVLSIEPD-QRS--------HLLEARQQLEE 255
            .|...:.:.||::...|   .:.|..:.||.|...:|.::|: ||:        :::...:.:.:
Human   199 ISTIDKVSVLDYLSYAV---YQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNK 260

  Fly   256 LITDGDKNGLLHLTARRPG---DYHESREFRMYEQVCRGE-LAPLPSKQRNLRCRL----RKSRL 312
            ..:|...:  ...|.::.|   ||...|:  .||.:|||| :...|.:|:.|.||.    |..:.
Human   261 SASDDQSD--QKTTPKKKGVAVDYLPERQ--KYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPKF 321

  Fly   313 GYAPFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGGNGGSTAAAFRTSQGAS 377
            ..||.|.|:....|.:::.|.:|...:.:.::..|:||:.|:||:. ...|..|.|.:|.|:.|.
Human   322 ILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHD-PETGKLTTAQYRVSKSAW 385

  Fly   378 FNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWDSFPENHIYQEGDLH----- 437
            .:...|.....::..:.|.:||::..||:|||||||:||.||||:|...::    |.|..
Human   386 LSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKD----EPDAFKELGT 446

  Fly   438 GNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRTKHAACPVLQGSKW 502
            |||:||.::|::||.|||.|.||.:...|.|::|:.:|||||..||:.|:.|:|||||||.|:||
Human   447 GNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKW 511

  Fly   503 IANVWIRERNQDNVRPCDL 521
            ::|.|:.||.|:..|||.|
Human   512 VSNKWLHERGQEFRRPCTL 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	39/131 (30%)
		P4Hc	336..509	CDD:214780	72/177 (41%)
P4HA1	NP_000908.2	P4Ha_N	25..112	CDD:400573	22/87 (25%)
		TPR	205..238		9/35 (26%)
		P4Hc	345..518	CDD:214780	72/177 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.930