Protein Alignment PH4alphaMP and p4ha2

DIOPT Version :10

• Sequence 1: NP_524594.2
• Gene: PH4alphaMP / 43624
• FlyBaseID: FBgn0026190
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: XP_012814344.2
• Gene: p4ha2 / 493342
• XenbaseID: XB-GENE-957618
• Length: 537
• Species: Xenopus tropicalis
• Alignment Length: 542
• Identity: 182/542 - (33%)
• Similarity: 292/542 - (53%)
• Gaps: 46/542 - (8%)

  Fly    10 LVLQVLSC----HGEFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQ---SEIDAIRVEH 67
            |:|..|.|    ..|.|:||..:..|...|..||..|:.|:.|..:....::   ||:|.:....
 Frog     8 LILLSLCCIWEVQTEVFTSTGQMTDLIFRERDLLQSLKEYIREEEERLSKIKRWASEVDELSSRS 72

  Fly    68 LNAADGIDDYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMASLKENLSFPSQDDFVG 132
            ....:|   ||.:||||::|:||.::||.:.|..|..||:: .::......:|  .||:::|..|
 Frog    73 TADPEG---YLGHPVNAYKLVKRFNTDWSSLENLVLQDSAK-GFIANFTFQRE--YFPTEEDETG 131

  Fly   133 SAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYNHTVPWLQQSMQLL 197
            :|.||.|:|.||:||...:|.|.|.|..|.:::|..|.|.:|:..|...||.|||.|:||:::.:
 Frog   132 AARALMRIQDTYKLDPDVIAKGKLPGTNYISSLSADDSFGMGKIAYHDGDYYHTVLWMQQALKQM 196

  Fly   198 --GEQSYGSESASLDFMEAVVEYHREMGAHESALSLVNHVLSIEPD-----QRSHLLEARQQLEE 255
              ||.:..::...||::...|   .::|....||.|...:|:::|:     ......|..|:.::
 Frog   197 DEGEDAVVNKVDVLDYLSYTV---FQLGDVPRALELTKRLLALDPNHDRAVNNLKYFEKMQEKQK 258

  Fly   256 LITDGDKNGLLHLTARRPG------DYHESREFRMYEQVCRGELAPL-PSKQRNLRCRL----RK 309
            .....:::.......|:||      ||...|:  :||.:||||...: |.:||.|.||.    |.
 Frog   259 AELKQNESTNTESATRQPGVYSRPLDYLPERD--VYEALCRGEGVKMNPRRQRRLFCRYHNGNRS 321

  Fly   310 SRLGYAPFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGGNGGSTAAAFRTSQ 374
            ..|..:|.|:|:....|.:|:....:..::...:::.|:|::.|:||.. ...|..:.|.:|.|:
 Frog   322 PYLILSPVKVEDEWDSPRIVRYLNALSDEEIAKIKELAKPKLARATVRD-PKTGVLSVANYRVSK 385

  Fly   375 GASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWDSFPENHIYQEGDLH-- 437
            .|....:.:.....::..:...:||.:|.||.|||||||:||.||||:|...::    |.|:.
 Frog   386 SAWLEENDDPVIARVNLRMQAITGLTVDTAELLQVANYGMGGQYEPHFDFSRKD----EPDVFKR 446

  Fly   438 ---GNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRTKHAACPVLQG 499
               |||:||.:.|::||||||.|.||.....:.|::|:.:|||||..||:.|:||:|||||||.|
 Frog   447 LGTGNRVATFLNYMSDVEAGGATVFPDFGAAIWPKKGTAVFWYNLFRSGEGDYRTRHAACPVLVG 511

  Fly   500 SKWIANVWIRERNQDNVRPCDL 521
            |||::|.|..||.|:.:|||.|
 Frog   512 SKWVSNKWFHERGQEFLRPCGL 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..158	CDD:462433	45/136 (33%)
		P4Hc	336..509	CDD:214780	71/177 (40%)
p4ha2	XP_012814344.2	P4Ha_N	26..157	CDD:462433	45/136 (33%)
		BepA	166..>247	CDD:443813	23/83 (28%)
		TPR repeat	166..201	CDD:276809	13/34 (38%)
		TPR repeat	206..236	CDD:276809	8/32 (25%)
		P4Hc	348..521	CDD:214780	71/177 (40%)