DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaMP and CG9698

DIOPT Version :9

Sequence 1:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	185/549 - (33%)
Similarity:	276/549 - (50%)	Gaps:	62/549 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLFLVLQ--VLSCHG-EFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEIDAIRVEHL 68
            ||||:..  :.|..| |||||...:.|:|..|..::..:|.::::.....:.|::.:.....|..
  Fly     8 VLFLLFHQAIPSVSGVEFFSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARLREFENERN 72

  Fly    69 NAADGIDDYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMASLKENLSFPSQDDFVGS 133
            .|.:....|..:|:|.:.|.|||..||:..| ::.|.|:....|..:...:...:.|.:.:..|:
  Fly    73 EAREWGPSYFESPINKYLLNKRLTVDWQRVE-NLMATSTGEKPLTRLRKFRNRETMPDKKELEGA 136

  Fly   134 AIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYN----HTVPWLQQSM 194
            ...|.|||..|:|...:||.|||:||.|||.::.:.|..:.:  .||||.:    |:  ||.::.
  Fly   137 IDGLLRLQYVYRLKAKDLARGILDGVDYGTQLNSEHCVDIAR--LALRDQHPRLAHS--WLIEAN 197

  Fly   195 QLL--GEQSYGSESASLDFMEAVVEYHREM----GAHESALSLVNHVLSIEPDQRSHLLEARQQL 253
            ..|  ||:   .|......:..:|:..:|:    |.:::...|:....:.|...:::........
  Fly   198 DRLTGGEK---EEQLKPQILALLVQAKKELEDFRGLNDTYQELIGIQSASEEHAKNYETFLNALS 259

  Fly   254 EELITDGDKNGLLHLTARRPGDYHESREFRMYEQVCRGELAPLPSKQRNLRCRLRKSRLGY---- 314
            |:.:.:..|..|.|  |..|.:.....||:.|...|.|.....|.:||:|||       ||
  Fly   260 EKALLNESKPILEH--APIPEEGEPVGEFQAYSLTCSGHWRLTPKEQRHLRC-------GYVTET 315

  Fly   315 ------APFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGGNGGSTAAAFRTS 373
                  ||.|.|||..|||:|..|.||...:.|.::|....|:.|:|:.|   :..|..:..|||
  Fly   316 HPFLWIAPLKAEELFQDPLLVLYHDVIYQSEIDVIRKLTENRLMRATITS---HNESVVSNVRTS 377

  Fly   374 QGASFNYSRNAATKLLS---RHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWDSFPENHIYQ--- 432
            |   |.:....|.|:||   :.|.|.:.|||.||||.|.|||||||||..|.|.|     ||
  Fly   378 Q---FTFIPVTAHKVLSTIDQRVADMTNLNMKYAEDHQFANYGIGGHYGQHMDWF-----YQTTF 434

  Fly   433 -----EGDLHGNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRTKHA 492
                 .....|||:||.::||:||..|||||||.|..|:.|::.:..||:|||.||..|.||:|.
  Fly   435 DAGLVSSPEMGNRIATVLFYLSDVAQGGGTAFPQLRTLLKPKKYAAAFWHNLHASGVGDVRTQHG 499

  Fly   493 ACPVLQGSKWIANVWIRERNQDNVRPCDL 521
            |||::.||||:.|.||||.:|.:.|||:|
  Fly   500 ACPIIAGSKWVQNRWIRENDQSDRRPCEL 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	32/131 (24%)
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	79/183 (43%)
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	32/131 (24%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	79/181 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461868
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	1	0.950	-	0	Normalized mean entropy	S3267
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.850