Protein Alignment PH4alphaMP and PH4alphaSG2

DIOPT Version :10

• Sequence 1: NP_524594.2
• Gene: PH4alphaMP / 43624
• FlyBaseID: FBgn0026190
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_651801.1
• Gene: PH4alphaSG2 / 43623
• FlyBaseID: FBgn0039779
• Length: 527
• Species: Drosophila melanogaster
• Alignment Length: 556
• Identity: 185/556 - (33%)
• Similarity: 291/556 - (52%)
• Gaps: 52/556 - (9%)

  Fly     1 MLLAKC----VLFLVLQVLSCHGEFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEID 61
            ||...|    :..|::.|...:|||:||...:..|.:.|..||...::||....:..:..:..::
  Fly     1 MLDRHCLYIGIFQLIIWVGVANGEFYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVE 65

  Fly    62 AIRVEHLNAAD--GIDDYLNNPVNAFRLIKRLHSDWET--FEGSVTADSSRSNYLDTMASLKENL 122
            .|:.||..|..  .:||||.:|::||||||||..||::  || .:.|:::|..:...:..|..:|
  Fly    66 QIKREHEWATSQLKLDDYLGHPLHAFRLIKRLVRDWDSLIFE-PILANNAREEFRAFVEVLSRDL 129

  Fly   123 SFPSQDDFVGSAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYNHTV 187
            .:|.|.:..|:...|.|||:.|.|..::||.||:.|:.||:.:.|::|:.:|..|:.|.:|..::
  Fly   130 GYPDQSELQGAIKGLARLQKVYNLATSDLADGIIGGLNYGSDLRWRECYEIGVQLFDLGEYQRSL 194

  Fly   188 PWLQQSMQLLGEQSYGSESASLDFMEAVVEY----HREMGAHESALSLVNHVLSIEPDQRSHLLE 248
            .|||.:..|| ..|...|..:..::..:.||    :.|:|..:.|..|::.:|..:|   :|..:
  Fly   195 EWLQVAFILL-RNSPREEKDADHYLSDIREYASMANFELGNPKKAARLLSQILESQP---THSAQ 255

  Fly   249 ARQQLEELITDGDKNGLLHLTARRPG-DYHESRE--FRMYEQVCRGELAPLPSKQRNLRCRLRKS 310
            ..|:              :|.:|.|| :..|::.  |..|.::|:|...|.......|||.|...
  Fly   256 QTQK--------------YLESRVPGKNVQETKPSWFSNYTRLCQGRRLPEERSGDPLRCYLDGK 306

  Fly   311 RLGY---APFKLEELHLDPLVVQLHQVIGSKDSDSL-QKTARPRIKRSTVYSLGGNGGSTAAAFR 371
            |..|   ||.::|.:||||.:...|.::.||...|: ::..:..:.||.|...||.|  |....|
  Fly   307 RHAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAVAGSGGEG--TVRDLR 369

  Fly   372 TSQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWDSF----PENHIYQ 432
            .||....:| ::.....:.|.:...||.:|..||.:||||||:||.||||.|.|    |:|
  Fly   370 VSQQTWLDY-KSPVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFEVNLPKN---- 429

  Fly   433 EGDLHGNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRTKHAACPVL 497
               ..|:|::|.::||:|||.||.|.|..|.:.:.|.:|:|:.|:|||.|...|.||.||.|||:
  Fly   430 ---FEGDRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVI 491

  Fly   498 QGSKWIANVWIRERNQDNVRPCDLERGQEISLHYRD 533
            .|||.|.|:|:....|:..|||:|......||.|||
  Fly   492 VGSKRIGNIWMHSGYQEFRRPCNLTSDSYKSLAYRD 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..158	CDD:462433	45/137 (33%)
		P4Hc	336..509	CDD:214780	71/177 (40%)
PH4alphaSG2	NP_651801.1	P4Ha_N	28..165	CDD:462433	45/137 (33%)
		CpoB	<178..263	CDD:441335	22/102 (22%)
		P4Hc	335..503	CDD:214780	71/177 (40%)