DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaMP and CG18233

DIOPT Version :9

Sequence 1:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	150/545 - (27%)
Similarity:	261/545 - (47%)	Gaps:	72/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AKCVLFLVLQVLSCHGEFF-------SSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEID 61
            |..||.||..:.|.....|       ||..||.||.:.|...:.....|.|.:.:..:.|...:|
  Fly     7 AAAVLILVQSIHSTDPNDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLD 71

  Fly    62 AIRVEHLNAADGIDDYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNY------LDTMASLKE 120
            |::..:....:..:.:::||:|||.||:||:.||...:          ||      |:.:.::::
  Fly    72 ALKRPNHKTHNEREKFVSNPLNAFGLIRRLNQDWPKLQ----------NYTQKPLGLEQLTAMQD 126

  Fly   121 NLS-FPSQDDFVGSAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYN 184
            .:| .|...|......|:.|::.||.|...::|.|:|...::...:.::||..|..|.:.:.::.
  Fly   127 IVSAAPESFDMNEKLKAMHRIETTYDLQPKDIAKGLLQRTEFNYRLLFRDCLALAYHKFEIGEFK 191

  Fly   185 HTVPWLQQSMQLLGEQSYGSESASLDFMEAVVEYHREMGAHESALS-----LVNHVL---SIEPD 241
            .::.|.|::::|       |...||:.|..:.|.  |:....:|::     |.|..|   :|:..
  Fly   192 RSLLWFQEALKL-------STDGSLEIMNRLKEI--ELKGFATAVAKRSIYLSNQGLTNETIDDM 247

  Fly   242 QRSHLLEAR-QQLEELITDGDKNGLLHLTARRPGDYHESREFRMYEQVCRGELAPLPSKQRNLRC 305
            ..|.|.:|: ..||:||:...|..:...:...|.|::..         ||| |.|   |:.||.|
  Fly   248 ANSQLQDAKLMDLEQLISSELKQWINDDSTTPPTDHNLG---------CRG-LFP---KKSNLVC 299

  Fly   306 RLRKSR---LGYAPFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGGNGGSTA 367
            |...|.   |..||.|:||:..||.:|..|:||..||.:.::..........|  |||......:
  Fly   300 RYNSSTNAFLKLAPLKMEEISRDPYIVMFHEVISDKDIEEMKGEITEMENGWT--SLGDPKEIVS 362

  Fly   368 AAFRTSQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWDSFPENHIYQ 432
            ..:...:.:||       :|.:::.:.|.:|..::....:|:||:|:||:::||:|.:.:.  .:
  Fly   363 RVYWIRKESSF-------SKRINQRISDMTGFKLEEFPAIQLANFGVGGYFKPHYDFYTDR--LK 418

  Fly   433 EGDLH---GNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRTKHAAC 494
            |.|::   |:|:.:.|:|..:|..||.|.||.|.:.|.|::|:.|||:|.......|.|:.|:.|
  Fly   419 EVDVNNTLGDRIGSIIFYAGEVSQGGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVC 483

  Fly   495 PVLQGSKWIANVWIRERNQDNVRPC 519
            |||.||:|....|:....|..|:||
  Fly   484 PVLVGSRWTITKWLHYAPQLFVKPC 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	35/138 (25%)
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	51/175 (29%)
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	35/138 (25%)
		ATP-synt_B	<198..278	CDD:304375	21/88 (24%)
		P4Hc	333..498	CDD:214780	51/175 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461828
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900