DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaMP and CG18234

DIOPT Version :9

Sequence 1:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_649043.3	Gene:	CG18234 / 40024	FlyBaseID:	FBgn0265268	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	135/572 - (23%)
Similarity:	249/572 - (43%)	Gaps:	103/572 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLAKCVLFLVLQVLSCHGEFFSST---SGLAKLFETEVVLLAELQNYVNEINQHAEALQSEIDA 62
            ::|:.|::.|...:..|  |..:|.   :|:.:|.:.|...::|:::|...:....:.::|.:..
  Fly     3 IILSICLISLGPPIGLC--EITNSAMSIAGMKELVDLEGFFISEMESYTAALKNKIDLMESLLQE 65

  Fly    63 IRVEHLNAADGIDDYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNY--LDTMASLKENL--S 123
            ::.:...:....::::.:|:|||.||:|||.||      ..|:....|.  |:.:.:::..|  :
  Fly    66 VQSKREISRRNPEEFVAHPLNAFSLIRRLHEDW------TQAELLMLNQVGLEHLQAIETGLEEA 124

  Fly   124 FPSQDDFVGSAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYN---H 185
            .||.:|...:...:..|||.|.|..:::|:|:|.|.:|..:::..:|..|..   |..::|   :
  Fly   125 QPSDNDLNDAIGGIISLQQFYNLQPSDIANGLLMGQQYNASLTTLNCQALAN---ACMNFNYDKY 186

  Fly   186 TVPWLQQSMQLLGEQSYGSESASL-DFM--EAVVEYHREM---GAHESALSLVNHVLSIEPDQRS 244
            .:.|.:.::....:...|.....: ||.  :..:.|...:   |..::|..::..|..::    :
  Fly   187 ALNWFKAAVDHYNDDRDGQVYREVFDFRLPDLYINYTSVLVTKGFRKAAWKVLQDVADLD----A 247

  Fly   245 HLLEARQQLEE-----------LITDG-DKNGLLHLTARRPGDYHESREFRMYEQVCRGELAPLP 297
            .|...|:.:.|           :||.. |..|.|.:                      |:.:
  Fly   248 TLWLLRKDIYEVGKIDVPDPTFIITPWFDVTGCLRV----------------------GQTS--- 287

  Fly   298 SKQRNLRCRLRKSR---LGYAPFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKR--STVY 357
               ::|.|...|:.   |..||.|:|.|.|.|.:|..|.||...:...::..:.|.:|.  ..:|
  Fly   288 ---QHLSCHYEKNTSEFLRIAPLKVETLSLKPHIVLYHDVIYDSEISKVKNISLPSLKSPLRILY 349

  Fly   358 SLGGNGGSTAAAFRTSQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHW 422
            ::..|             ..|...|......||..:.|.:|.::....|.|:.||||.|....|.
  Fly   350 AIDYN-------------LKFAKIREDHQSPLSLRIKDMTGEDVQEDTDFQIDNYGICGFRNFHT 401

  Fly   423 DSFPENHIYQEGDLHGNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNL----HPSG 483
            |:.....  |..:| |:|:.:.::::.||..||..|||.|.|.:.|::||.|.|.||    .|:.
  Fly   402 DNIELQD--QTAEL-GDRLTSIMFFMNDVAQGGALAFPNLNLTIWPQKGSALVWRNLDHRMQPNQ 463

  Fly   484 DQDFRTKHAACPVLQGSKWIANVWIRERNQDNVRPCDLER---GQEISLHYR 532
            |    ..|.:|||:.||||....|:.||.|...|||...|   ..:.|:.:|
  Fly   464 D----LLHVSCPVVVGSKWTLVKWLHERPQMFSRPCTTGRKFKSHDQSMKFR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	32/138 (23%)
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	50/178 (28%)
CG18234	NP_649043.3	P4Ha_N	27..157	CDD:285528	31/135 (23%)
CG18234	NP_649043.3	P4Hc	<371..485	CDD:214780	42/120 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461938
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.900