Protein Alignment PH4alphaMP and p4ha2

DIOPT Version :10

• Sequence 1: NP_524594.2
• Gene: PH4alphaMP / 43624
• FlyBaseID: FBgn0026190
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: XP_005173949.1
• Gene: p4ha2 / 373132
• ZFINID: ZDB-GENE-030827-1
• Length: 542
• Species: Danio rerio
• Alignment Length: 555
• Identity: 193/555 - (34%)
• Similarity: 298/555 - (53%)
• Gaps: 53/555 - (9%)

  Fly     3 LAKCVLFLVLQVLS----CHGEFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQS---EI 60
            :|..::|| |..||    ...|.|:|...:..|..||..|:..|:.|:....|..|.::|   ::
Zfish     1 MAAFLVFL-LSTLSFSSPTRAEIFTSIGQMTNLIFTERELVQSLKEYIQAEEQKLETVRSWANKL 64

  Fly    61 DAIRVEHLNAADGIDDYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMASLKENLSFP 125
            |.:.....:..:|   :|.:||||::|:|||:::|...|..|..|.| ..::..|:..::  .||
Zfish    65 DKLTRTSTSDPEG---FLAHPVNAYKLMKRLNTEWSELESLVLQDPS-DGFISNMSVHRQ--YFP 123

  Fly   126 SQDDFVGSAIALTRLQQTYQLDVAELASGIL------NGVKYGTAMSWQDCFVLGQHLYALRDYN 184
            .::|..|:|.||.|||.||:||....:.|.|      :||:|...::..|||.:|:..|...||.
Zfish   124 DEEDEKGAAKALLRLQDTYKLDAESFSKGKLPGQRQHSGVRYNALLTVDDCFDMGKMAYNDNDYY 188

  Fly   185 HTVPWLQQSMQLL--GEQSYGSESASLDFMEAVVEYHREMGAHESALSLVNHVLSIEPD-QRS-- 244
            |:|.|:|||::.:  ||::...::..||::...|   .:||....|:.|...:|:|:|. ||:
Zfish   189 HSVLWMQQSLRQMDSGEEAKTPKADVLDYLSYSV---YQMGDLPRAIELTRRLLAIDPSHQRAGG 250

  Fly   245 HLLEARQQLEELITD--------GDKNGLLHLTARRPGDYHESREFRMYEQVCRGELAPLPSK-Q 300
            :|....:.|.:.:.|        .|:..:...|.:||.||...||  .||.:||||...:.:| |
Zfish   251 NLRYFERLLSKELQDSGQTQPEPADERPIQLDTYQRPKDYLPERE--AYEALCRGEGVKMTTKRQ 313

  Fly   301 RNLRCRL----RKSRLGYAPFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGG 361
            ..|.||.    |..||...|.|.|:....|.:|:..:.:..::...:::.|.|::.|:||.. ..
Zfish   314 SRLFCRYRDGNRNPRLLLKPMKEEDEWDSPHIVRFLEALSDEEIQKIKEIATPKLARATVRD-PK 377

  Fly   362 NGGSTAAAFRTSQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWDSFP 426
            .|..|.|.:|.|:.|......:.....:::.:.|.:||.:|.||.|||||||:||.||||:|...
Zfish   378 TGVLTVAHYRVSKSAWLEGEDDPVIARVNQRIEDITGLTVDTAELLQVANYGVGGQYEPHFDFSR 442

  Fly   427 ENHIYQEGDLH-----GNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQD 486
            ::    |.|..     |||:||.:.|::||||||.|.||.....|.|.:|:.:|||||..||:.|
Zfish   443 KD----EPDAFKSLGTGNRVATYLNYMSDVEAGGATVFPDFGASVWPRKGTAVFWYNLFRSGEGD 503

  Fly   487 FRTKHAACPVLQGSKWIANVWIRERNQDNVRPCDL 521
            :||:|||||||.||||::|.||.||.|:..|||.|
Zfish   504 YRTRHAACPVLVGSKWVSNKWIHERGQEFRRPCGL 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..158	CDD:462433	43/142 (30%)
		P4Hc	336..509	CDD:214780	74/177 (42%)
p4ha2	XP_005173949.1	P4Ha_N	25..156	CDD:462433	43/136 (32%)
		NrfG	177..280	CDD:443378	28/105 (27%)
		P4Hc	353..526	CDD:214780	74/177 (42%)