Protein Alignment PH4alphaMP and P4ha3

DIOPT Version :10

• Sequence 1: NP_524594.2
• Gene: PH4alphaMP / 43624
• FlyBaseID: FBgn0026190
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: XP_063123241.1
• Gene: P4ha3 / 361612
• RGDID: 735150
• Length: 584
• Species: Rattus norvegicus
• Alignment Length: 539
• Identity: 160/539 - (29%)
• Similarity: 254/539 - (47%)
• Gaps: 85/539 - (15%)

  Fly    22 FSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEIDAIRVEHLNAADGIDDYLNNPVNAFR 86
            ||:.:.:|:....|..||..|:.|:    :..||...::.....:.|:..:.:...:.||:.||.
  Rat    31 FSALTSVARALAPERRLLGTLRRYL----RGEEARLRDLTRFYDKVLSLHEDLKIPVVNPLLAFT 91

  Fly    87 LIKRLHSDWETFEGSVTADSSRSNYLDTMASLKENLSFPSQDDFVGSAIALTRLQQTYQLDVAEL 151
            |||||.|||.....|:.|..:.....|....::::|  |:.:|..|:|.||.|||..|.|:|..|
  Rat    92 LIKRLQSDWRNVVHSLEATENIRALKDGYEKVEQDL--PAFEDLEGAARALMRLQDVYMLNVKGL 154

  Fly   152 ASGILNGVKYGT-----------AMSWQDCFVLGQHLYALRDYNHTVPWLQQSMQLLGEQSYG-- 203
            |.|:...|...:           :::..|||.:|:..|...||.|.:|||::::.|. .:|||
  Rat   155 AQGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKVAYDTGDYYHAIPWLEEAVSLF-RRSYGEW 218

  Fly   204 --SESASL-DFMEAVVEYHREMGAHESALSLVNHVLSIEPDQRSHLLEARQQL--EELITDGDKN 263
              .:.||| |.::.:.....::|....||||....|...||.:.   .||..|  |.|:.:   |
  Rat   219 KTEDEASLEDALDYLAFACYQVGNVSCALSLSREFLVYSPDNKR---MARNVLKYERLLAE---N 277

  Fly   264 GLLHLTA-----RRPGDYH-ESREFRMYEQVCRGELAPLPSKQR--NLRCRLRKSRLGY---APF 317
            |  ||.|     :||...| ::|:  .||.:|: .|...|:..:  :|.|....:...|   .|.
  Rat   278 G--HLMAAETAIQRPNVPHLQTRD--TYEGLCQ-TLGSQPTHYQIPSLYCSYETNSSPYLLLQPA 337

  Fly   318 KLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGGNGGSTAAAFRTSQGASFNYSR 382
            :.|.:||.|||...|..:..:::..:::.|.|.::||.|.|   ........:|.|:.|....:.
  Rat   338 RKEVIHLRPLVALYHDFVSDEEAQKIRELAEPWLQRSVVAS---GEKQLQVEYRISKSAWLKDTV 399

  Fly   383 NAATKLLSRHVGDFSGLNMD--YAEDLQVANYGIGGHYEPHWD--SFPENHIYQEGDLHGNRMAT 443
            :.....|.|.:...:||::.  |||.|||.|||||||||||:|  :.|.:.:|:...  |||:||
  Rat   400 DPVLVTLDRRIAALTGLDIQPPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYKMKS--GNRVAT 462

  Fly   444 GIYYLADVEAGGGTAFPF----LPLL-------------VTPERGSL-------LFWYNLH---P 481
            .:.||:.|||||.|||.:    :|::             ...|||.:       |.|:...   .
  Rat   463 LMIYLSSVEAGGATAFIYGNFSVPVVKVRGMLHCFGGTCTGVERGMMTHFTLAALCWWETSGWPT 527

  Fly   482 SG--DQDFRTKHAACPVLQ 498
            ||  ..|..::..|.|:|:
  Rat   528 SGYTSMDRNSEDPAAPILK 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..158	CDD:462433	40/133 (30%)
		P4Hc	336..509	CDD:214780	60/196 (31%)
P4ha3	XP_063123241.1	None