DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaMP and P4ha2

DIOPT Version :9

Sequence 1:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	193/550 - (35%)
Similarity:	299/550 - (54%)	Gaps:	62/550 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLFLVLQ---VLS-CHGEFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEIDAIRVEH 67
            ||.|::.   ||| ...|||:|...:..|...|..|:..|:.|:  :.:.|:..:.:..|.::|.
  Rat     5 VLVLLMSWFGVLSWVQAEFFTSIGHMTDLIYAEKDLVQSLKEYI--LAEEAKLSKIKSWASKMEA 67

  Fly    68 LNAADGID--DYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMASLKENLS-----FP 125
            |.:....|  .||.:||||::|:|||::||......|..|::        |....|||     ||
  Rat    68 LTSKSAADPEGYLAHPVNAYKLVKRLNTDWPALGDLVLQDAA--------AGFVANLSVQRQFFP 124

  Fly   126 SQDDFVGSAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYNHTVPWL 190
            :.:|..|:|.||.|||.||:||...::.|.|.|.||...:|..|||.:|:..|...||.|||.|:
  Rat   125 TDEDESGAARALMRLQDTYKLDPDMISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWM 189

  Fly   191 QQSMQLL--GEQSYGSESASLDFMEAVVEYHREMGAHESALSLVNHVLSIEPDQR---------S 244
            :|.::.|  ||::..::|..||::...|   .::|....|:.|...:||::|...         .
  Rat   190 EQVLKQLDAGEEATVTKSLVLDYLSYAV---FQLGDLHRAVELTRRLLSLDPSHERAGGNLRYFE 251

  Fly   245 HLLEARQQLEELITDGDKNGL-----LHLTARRPGDYHESREFRMYEQVCRGE-LAPLPSKQRNL 303
            .|||  ::..:.:::....||     |:   .||.||...|:  :||.:|||| :...|.:|:.|
  Rat   252 RLLE--EERGKSLSNQTDAGLASQENLY---ERPVDYLPERD--VYESLCRGEGIKMTPRRQKRL 309

  Fly   304 RCRL----RKSRLGYAPFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGGNGG 364
            .||.    |..:|..||||.|:....|.:|:.:.|:..::.:.:::.|:|::.|:||.. ...|.
  Rat   310 FCRYHHGNRVPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRD-PKTGV 373

  Fly   365 STAAAFRTSQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWDSFPENH 429
            .|.|::|.|:.:......:.....::|.:...:||.:..||.|||||||:||.||||:| |..:
  Rat   374 LTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFD-FSRS- 436

  Fly   430 IYQEGDLH-----GNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRT 489
              .|.|..     |||:||.:.|::||||||.|.||.|...:.|::|:.:|||||..||:.|:||
  Rat   437 --DERDAFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRT 499

  Fly   490 KHAACPVLQGSKWIANVWIRERNQDNVRPC 519
            :|||||||.|.||::|.|..||.|:.:|||
  Rat   500 RHAACPVLVGCKWVSNKWFHERGQEFLRPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	44/138 (32%)
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	72/177 (41%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	22/78 (28%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	72/177 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930