DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaMP and CG31013

DIOPT Version :9

Sequence 1:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	161/539 - (29%)
Similarity:	250/539 - (46%)	Gaps:	97/539 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LAKLFETEVVLLAELQNYVNEINQHAEALQSEIDAIRVEHLNAADGIDDYLNNPVNAFRLIKRLH 92
            :..|.|.|..|:..|:||.|.:.|..|.::|::..||.|:.........||:||:|.|.:|:|||
  Fly    35 MVPLLELEKKLIDNLENYTNALEQKLEIIRSQLLVIRAENEKGRRNAISYLSNPLNGFSIIRRLH 99

  Fly    93 SDW----ETFEGSVTADSSRSNYLDTMASLKENLSFPSQDDFVGSAIALTRLQQTYQLDVAELAS 153
            .||    :..|..|.....::.|     |.|:.|  |::.|...:...:.|:|.||.|.|.:..:
  Fly   100 QDWINWRKYMEQPVGIWQLKAFY-----SWKDEL--PTERDLWDACEGIARIQSTYDLKVGDFIN 157

  Fly   154 GILNGVKYGTAMSWQDCFVLGQHLYALRDYNHTVPWLQQSMQLLGE----QSYGSESASLDFMEA 214
            |.:||.:|..:||..|...:|.:|:.....:..:.|||:..|.|.|    |........:|.:..
  Fly   158 GNINGKQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQEVPQRLQEELLIQPRHLPIKEVDALRL 222

  Fly   215 VVEYHREMGAHESALSLVNHVLSIEPDQRSHLLEARQQLEELITDGDKNGLLHLTARRPGDYHES 279
            :.|...:...:..||.|:::.|.::|                                    |::
  Fly   223 LAEAQIKDQNYSEALPLLHNCLKLQP------------------------------------HDA 251

  Fly   280 REFRMYEQVC-----RGELAPLPSKQRN--------LRCR--LRKSR-------------LGYAP 316
            |..|::::..     :.:.:|..:|:||        |.|.  |..|.             |..||
  Fly   252 RVLRLWKKTTDFIENQPDQSPTENKKRNVPIANAFKLSCNGPLESSTRLHCFYNFTTTPFLRLAP 316

  Fly   317 FKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGG----NGGSTAAAFRTSQGAS 377
            .|.|::.|||.||..|:|:.:::...|...|...:|.:.::....    |.|      ||::|..
  Fly   317 LKTEQIGLDPYVVLYHEVLSAREISMLIGKAAQNMKNTKIHKERAVPKKNRG------RTAKGFW 375

  Fly   378 FNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWDSF---PENHIYQEG----D 435
            .....|..||.::|.:.|.:|.::..:|..||.||||||||..|.|.|   ..||.....    |
  Fly   376 LKKESNELTKRITRRIMDMTGFDLADSEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSID 440

  Fly   436 LHGNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRTKHAACPVLQGS 500
            | |:|:||.::||.|||.||.|.|..:...|:|:.|:.:|||||...|:.|.||:||||||:.||
  Fly   441 L-GDRIATVLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGS 504

  Fly   501 KWIANVWIRERNQDNVRPC 519
            ||:...||||:.|..:|||
  Fly   505 KWVMTEWIREKRQIFIRPC 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	41/131 (31%)
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	68/183 (37%)
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	41/131 (31%)
		TPR_11	178..248	CDD:290150	15/69 (22%)
		TPR repeat	211..246	CDD:276809	6/34 (18%)
		P4Hc	336..513	CDD:214780	68/183 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461836
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900