DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaMP and CG32201

DIOPT Version :9

Sequence 1:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_730346.2	Gene:	CG32201 / 317911	FlyBaseID:	FBgn0052201	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	141/524 - (26%)
Similarity:	242/524 - (46%)	Gaps:	63/524 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEIDAIRVEHLNAADGIDDYLNNPVNAF 85
            :.|||.||.||.:.|......|.|.|:::.:..|||:..:.::..|...:.:....|::||:|||
  Fly    33 YSSSTVGLLKLLKVEEKFTDNLLNQVDQLGEKFEALRMYLSSVGYELHRSLNEKVQYVSNPINAF 97

  Fly    86 RLIKRLHSD---WETFEGSVTADSSRSNYLDTMASLKENLSFPSQDDFVGSAIALTRLQQTYQLD 147
            .|::|.|.|   |..:......:.::|..:|.:..:      |:..|.:.:...:.|:::.|.|.
  Fly    98 SLLRRTHEDLPKWHEYFKEAIGEGNQSILVDLVKMV------PNDVDMLSAMHGIQRIEKIYDLK 156

  Fly   148 VAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYNHTVPWL------------QQSMQLLGEQ 200
            :.:||.|:|.||:|...::::|...:|..:|...||.....|.            |..:|:||:.
  Fly   157 IDDLAQGVLQGVQYNVQLTYRDLIAMGNSMYQQSDYQTAAKWYRIACKRELENPEQLFIQILGDP 221

  Fly   201 SYGSESASLDFMEAVVEYHREMGAHESALSLVNHVLSIEPDQRSHLLEARQQLEELITDGDKNGL 265
               ||.....:::::.:|...  ..|.:.|:....:.::..| ..|......|.|...|.:....
  Fly   222 ---SEHLHRQYIKSLFKYGST--TSEPSKSIEEAFIMVQASQ-EELDNIMSDLNEPQNDVEVEKD 280

  Fly   266 LHLTARRPGDYHESREFRMYEQVCRGELAPLPSKQRNLRCRLRKSR---LGYAPFKLEELHLDPL 327
            |:...|.|.:         .|..|||    |..::.||.||.:.:.   |..||.||||:.|||.
  Fly   281 LYQVKRSPSN---------CELGCRG----LYRQKTNLVCRYKSTANTFLRLAPLKLEEISLDPF 332

  Fly   328 VVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGGNG---GSTAAAFRTSQGASFNYSRNAATKLL 389
            :...|:|:...:...|:..:...:..   |:...||   ..|...:......|....|      :
  Fly   333 MAMYHEVLYDSEIRELKGQSMNMVNG---YASQRNGTEIRDTVVRYDWWSNTSLVRER------I 388

  Fly   390 SRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHW----DSFPENHIYQEGDLHGNRMATGIYYLAD 450
            ::.:.|.:|.|....|.||:||||:|.:::||:    |.|...:|...||    |:|:.::|.::
  Fly   389 NQRIIDMTGFNFLKDEKLQIANYGLGTYFQPHFDYSSDGFETPNITTLGD----RLASILFYASE 449

  Fly   451 VEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRTKHAACPVLQGSKWIANVWIRERNQDN 515
            |..||.|.||.:.:.|.|::||:|:|:|||..|..|.|:.|:.||||.|.:|....|:....|..
  Fly   450 VPQGGATVFPEINVTVFPQKGSMLYWFNLHDDGKPDIRSLHSVCPVLNGDRWTLTKWVPMFPQMF 514

  Fly   516 VRPC 519
            ..||
  Fly   515 SFPC 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	35/134 (26%)
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	54/179 (30%)
CG32201	NP_730346.2	P4Ha_N	36..165	CDD:285528	35/134 (26%)
CG32201	NP_730346.2	P4Hc	341..507	CDD:214780	53/178 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461823
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900