Protein Alignment PH4alphaMP and P4HA3

DIOPT Version :10

• Sequence 1: NP_524594.2
• Gene: PH4alphaMP / 43624
• FlyBaseID: FBgn0026190
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_001275677.1
• Gene: P4HA3 / 283208
• HGNCID: 30135
• Length: 604
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 162/580 - (27%)
• Similarity: 254/580 - (43%)
• Gaps: 96/580 - (16%)

  Fly    16 SCHGEFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEIDAIRVEHLNAADGIDDYLNN 80
            :..|:.||:.:.:|:....|..||..|:.|:.........|....|.:...|.::...:    .|
Human    25 AARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRFYDKVLSLHEDSTTPV----AN 85

  Fly    81 PVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMASLKENLSFPSQDDFVGSAIALTRLQQTYQ 145
            |:.||.|||||.|||.....|:.|..:.....|....::::|  |:.:|..|:|.||.|||..|.
Human    86 PLLAFTLIKRLQSDWRNVVHSLEASENIRALKDGYEKVEQDL--PAFEDLEGAARALMRLQDVYM 148

  Fly   146 LDVAELASGILNGVKYGTA------------MSWQDCFVLGQHLYALRDYNHTVPWLQQSMQLLG 198
            |:|..||.|:...|. |:|            ::..|||.:|:..|.:.||.|.:|||::::.|.
Human   149 LNVKGLARGVFQRVT-GSAITDLYSPKRLFSLTGDDCFQVGKVAYDMGDYYHAIPWLEEAVSLF- 211

  Fly   199 EQSYG----SESASL-DFMEAVVEYHREMGAHESALSLVNHVLSIEPDQRSHLLEARQQL--EEL 256
            ..|||    .:.||| |.::.:...:...|....||||....|...||.:.   .||..|  |.|
Human   212 RGSYGEWKTEDEASLEDALDHLAFAYFRAGNVSCALSLSREFLLYSPDNKR---MARNVLKYERL 273

  Fly   257 ITDGDKNGLLHLTARRPGDYH-ESREFRMYEQVC-----RGELAPLPSKQRNLRCRLRKSRLGY- 314
            :.:...:.:.....:||...| ::|:  .||.:|     :..|..:||    |.|....:...|
Human   274 LAESPNHVVAEAVIQRPNIPHLQTRD--TYEGLCQTLGSQPTLYQIPS----LYCSYETNSNAYL 332

  Fly   315 --APFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGGNGGSTAAAFRTSQGAS 377
              .|.:.|.:||:|.:...|..:...::..:::.|.|.::||.|.|   ........:|.|:.|.
Human   333 LLQPIRKEVIHLEPYIALYHDFVSDSEAQKIRELAEPWLQRSVVAS---GEKQLQVEYRISKSAW 394

  Fly   378 FNYSRNAATKLLSRHVGDFSGLNM--DYAEDLQVANYGIGGHYEPHWD--SFPENHIYQEGDLHG 438
            ...:.:.....|:..:...:||::  .|||.|||.|||||||||||:|  :.|.:.:|:...  |
Human   395 LKDTVDPKLVTLNHRIAALTGLDVRPPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMKS--G 457

  Fly   439 NRMATGIYYLADVEAGGGTAFPFLPLLVTPERG-------------------SLLFWYNLH---P 481
            ||:||.:.||:.|||||.|||.:..|.|...|.                   ::|.|:.:.   .
Human   458 NRVATFMIYLSSVEAGGATAFIYANLSVPVVRHCFGGTCTGVVKGTVTHFMLAVLSWWEISGWPT 522

  Fly   482 SG--DQDFRTKHAACPVLQGSKWIANVW----IRERNQD--------------NVRPCDL 521
            ||  ..|..:...|.|.|:........|    ..:|:|:              ..|||.|
Human   523 SGYMSMDRNSADPAAPALKTELLAERSWWSPVAFQRSQEPKAGVGEEKAEQPPGRRPCQL 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..158	CDD:462433	40/133 (30%)
		P4Hc	336..509	CDD:214780	59/204 (29%)
P4HA3	NP_001275677.1	P4Ha_N	58..160	CDD:462433	34/107 (32%)
		BepA	<188..289	CDD:443813	29/104 (28%)
		P4Hc	356..>478	CDD:214780	45/126 (36%)