Protein Alignment PH4alphaMP and P4ha2

DIOPT Version :9

• Sequence 1: NP_524594.2
• Gene: PH4alphaMP / 43624
• FlyBaseID: FBgn0026190
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: XP_006532515.1
• Gene: P4ha2 / 18452
• MGIID: 894286
• Length: 557
• Species: Mus musculus
• Alignment Length: 573
• Identity: 198/573 - (34%)
• Similarity: 304/573 - (53%)
• Gaps: 76/573 - (13%)

  Fly     1 MLLAKCVLFLVLQ---VLS-CHGEFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEID 61
            |.|...||.|::.   ||| ...|||:|...:..|...|..|:..|:.|:  :.:.|:..:.:..
Mouse     1 MKLQVLVLVLLMSWFGVLSWVQAEFFTSIGHMTDLIYAEKDLVQSLKEYI--LVEEAKLAKIKSW 63

  Fly    62 AIRVEHLNAADGID--DYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMASLKENLS- 123
            |.::|.|.:....|  .||.:||||::|:|||::||......|..|:|        |....|||
Mouse    64 ASKMEALTSRSAADPEGYLAHPVNAYKLVKRLNTDWPALGDLVLQDAS--------AGFVANLSV 120

  Fly   124 ----FPSQDDFVGSAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYN 184
                ||:.:|..|:|.||.|||.||:||...::.|.|.|.||...:|..|||.||:..|...||.
Mouse   121 QRQFFPTDEDESGAARALMRLQDTYKLDPDTISRGELPGTKYQAMLSVDDCFGLGRSAYNEGDYY 185

  Fly   185 HTVPWLQQSMQLL--GEQSYGSESASLDFMEAVVEYHREMGAHESALSLVNHVLSIEPDQR---- 243
            |||.|::|.::.|  ||::..::|..||::...|   .::|....|:.|...:||::|...
Mouse   186 HTVLWMEQVLKQLDAGEEATVTKSLVLDYLSYAV---FQLGDLHRAVELTRRLLSLDPSHERAGG 247

  Fly   244 -----SHLLEARQQLEELITDGDKNGL-----LHLTARRPGDYHESREFRMYEQVCRGELAPL-P 297
                 ..|||  ::..:.:::....||     |:   .||.||...|:  :||.:||||...| |
Mouse   248 NLRYFERLLE--EERGKSLSNQTDAGLATQENLY---ERPTDYLPERD--VYESLCRGEGVKLTP 305

  Fly   298 SKQRNLRCRL----RKSRLGYAPFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYS 358
            .:|:.|.||.    |..:|..||||.|:....|.:|:.:.|:..::.:.:::.|:|::.|:||..
Mouse   306 RRQKKLFCRYHHGNRVPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRD 370

  Fly   359 LGGNGGSTAAAFRTSQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWD 423
             ...|..|.|::|.|:.:......:.....::|.:...:||.:..||.|||||||:||.||||:|
Mouse   371 -PKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFD 434

  Fly   424 ----SFPENHIYQEGDL------------------HGNRMATGIYYLADVEAGGGTAFPFLPLLV 466
                .| ::.:..||:.                  .|||:||.:.|::||||||.|.||.|...:
Mouse   435 FSRRPF-DSGLKTEGNRLATFLNYSDEQDAFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAI 498

  Fly   467 TPERGSLLFWYNLHPSGDQDFRTKHAACPVLQGSKWIANVWIRERNQDNVRPC 519
            .|::|:.:|||||..||:.|:||:|||||||.|.||::|.|..||.|:.:|||
Mouse   499 WPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	45/138 (33%)
		P4Hc	336..509	CDD:214780	72/194 (37%)
P4ha2	XP_006532515.1	P4Ha_N	28..157	CDD:369820	45/138 (33%)
		P4Hc	348..541	CDD:214780	72/194 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3267
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.880