DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaSG2 and P4htm

DIOPT Version :9

Sequence 1:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_083220.3	Gene:	P4htm / 74443	MGIID:	1921693	Length:	503	Species:	Mus musculus

Alignment Length:	336	Identity:	84/336 - (25%)
Similarity:	122/336 - (36%)	Gaps:	122/336 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 SQIL---ESQPTHSAQQTQ-----KYLESRVPGK-NVQETKPSWFSNYTRLCQGRRLPEERSGDP 298
            ||||   |.:...||.|..     :.|:....|: .::|....     |||..||.:..|...:
Mouse   172 SQILPTEEYEEAMSAMQVSQLDLFQLLDQNHDGRLQLREVLAQ-----TRLGNGRWMTPENIQE- 230

  Fly   299 LRCYLDGKRHAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSI----------FEEADKEEMVR 353
                              ....:..|||.:   |:||.::..::          ..:|:..|:||
Mouse   231 ------------------MYSAIKADPDGD---GVLSLQEFSNMDLRDFHKYMRSHKAESNELVR 274

  Fly   354 SA-----VAGSGGEGTVRDL--RVSQQTWLDYKSPVMNSVGRIIQFVSGFDMAGAEHMQVANYGV 411
            ::     ..|.|....:|.:  ||.:.|.|   ||      .|::|        :|.:||..||.
Mouse   275 NSHHTWLHQGEGAHHVMRAIRQRVLRLTRL---SP------EIVEF--------SEPLQVVRYGE 322

  Fly   412 GGQYEPH----PDYFE---------VNLPKNFEGD-RISTSMFYLSDVEQGGYTVF--------- 453
            ||.|..|    |.|.|         .|....||.. |..|.:|||::|..||.|||
Mouse   323 GGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYD 387

  Fly   454 ------------------TKLNVFLPPVKGALVMWHNLHRSL--------HVDARTLHAGCPVIV 492
                              .|.|:.:.|.:|..|.|:|.   |        .||..:||.||.|..
Mouse   388 EMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNY---LPDGQGWVGEVDDYSLHGGCLVTR 449

  Fly   493 GSKRIGNIWMH 503
            |:|.|.|.|::
Mouse   450 GTKWIANNWIN 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	62/233 (27%)
P4htm	NP_083220.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..110
		EF-hand_7	193..253	CDD:290234	15/86 (17%)
		EFh	195..253	CDD:298682	15/84 (18%)
		P4Hc	247..459	CDD:214780	60/231 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839368
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740