DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaSG2 and P4ha1

DIOPT Version :9

Sequence 1:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_742059.2	Gene:	P4ha1 / 64475	RGDID:	621000	Length:	534	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	174/543 - (32%)
Similarity:	278/543 - (51%)	Gaps:	53/543 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IIW----VGV------ANGEFYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIKR 69
            :||    :|:      |:..|::|:..|.||...|::|:.:.:.|:::::.:|:..:::.|::.|
  Rat     1 MIWGVLMMGILLPQCSAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDR 65

  Fly    70 EHEWATSQLKLDDYLGHPLHAFRLIKRLVRDWDSLIFEPILANNAREEFRAFVEVLSRDLGY-PD 133
            ....||..  .:.::|||::||:|:|||..:|..|  |.::..:..:   .|:..|:....| |:
  Rat    66 LTSTATKD--PEGFVGHPVNAFKLMKRLNTEWSEL--ENLILKDMSD---GFISNLTIQRQYFPN 123

  Fly   134 QSELQGAIKGLARLQKVYNLATSDLADGIIGGLNYGSDLRWRECYEIGVQLFDLGEYQRSLEWLQ 198
            ..:..||.|.|.|||..|||.|:.::.|.:.|:.:.|.|...:|:|:|...:...:|..:..|::
  Rat   124 DEDQVGAAKALFRLQDTYNLDTNTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWME 188

  Fly   199 VAFILLRNSPREEKDADHYLSDIREYASMANFELGNPKKAARLLSQILESQPTHSAQQTQ----K 259
            .|.:.|........|.    ..:.:|.|.|.::.|:..||..|..::||..|.|......    :
  Rat   189 QALMQLEEGEMSTVDK----VSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFE 249

  Fly   260 YLESRVPGKNV--------QETKPS----------WFSNYTRLCQGRRLP-EERSGDPLRC-YLD 304
            |:.|:....|.        |:|.|.          ....|..||:|..:. ..|....|.| |.|
  Rat   250 YIMSKEKDANKSASGDQSDQKTTPKKKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYHD 314

  Fly   305 GKRHAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAVAG-SGGEGTVRDL 368
            |.|:..|.|||.:.|.....|.|..:|.::|..:| .|.::..|..:.|:.|.. ..|:.|....
  Rat   315 GNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEI-EIVKDLAKPRLSRATVHDPETGKLTTAQY 378

  Fly   369 RVSQQTWLD-YKSPVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFEVNLPKNFE- 431
            |||:..||. |:.||::.:...||.::|.|::.||.:||||||||||||||.|:...:.|..|.
  Rat   379 RVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRE 443

  Fly   432 ---GDRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVIVG 493
               |:||:|.:||:|||..||.|||.::...:.|.||..|.|:||..|...|..|.||.|||:||
  Rat   444 LGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVG 508

  Fly   494 SKRIGNIWMHSGYQEFRRPCNLT 516
            :|.:.|.|:|...|||||||.|:
  Rat   509 NKWVSNKWLHERGQEFRRPCTLS 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	40/135 (30%)
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	73/173 (42%)
P4ha1	NP_742059.2	P4Ha_N	25..112	CDD:400573	24/93 (26%)
		TPR	205..238		10/32 (31%)
		P4Hc	345..518	CDD:214780	73/173 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820