Protein Alignment PH4alphaSG2 and P4HTM

DIOPT Version :9

• Sequence 1: NP_651801.1
• Gene: PH4alphaSG2 / 43623
• FlyBaseID: FBgn0039779
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_808807.2
• Gene: P4HTM / 54681
• HGNCID: 28858
• Length: 563
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 124/635 - (19%)
• Similarity: 184/635 - (28%)
• Gaps: 322/635 - (50%)

  Fly     7 LYIG-IFQLIIWVGVANGEFYSSVDSMQDLAQ---VEEELLNATRSYVESQQKQLDFYRRYVEQI 67
            ||:| :..|:::|..:||: .||....|..||   .|..|...||                :|.|
Human    70 LYLGNVLALLLFVHYSNGD-ESSDPGPQHRAQGPGPEPTLGPLTR----------------LEGI 117

  Fly    68 KREHEWATSQLKLDDYLGHPLHAFRLIKRLVRDWD----SLIFEPILAN----NAREEFRAFVEV 124
            |..||                   |.: :||.|.|    :|..:|:|..    ...||.|..:.:
Human   118 KVGHE-------------------RKV-QLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHL 162

  Fly   125 LSRDLGYPDQSELQGAIKGLARLQKVYNLATSDLADGIIGGLNYGSDLRWRECYEIGVQLFDLGE 189
                          ..:|||.|                                   .|:....|
Human   163 --------------AQMKGLQR-----------------------------------SQILPTEE 178

  Fly   190 YQRSLEWLQVA----FILLRNSPREEKDADHYLSDIREYASMANFELGN-----PKKAARLLSQI 245
            |:.::..:||:    |.||      :::.|.:| .:||.  :|...|||     |:
Human   179 YEEAMSTMQVSQLDLFRLL------DQNRDGHL-QLREV--LAQTRLGNGWWMTPE--------- 225

  Fly   246 LESQPTHSAQQTQKYLESRVPGKNV---QETKPSWFSNYTRLCQGRRLPEERSGDPLRCYLDGKR 307
                   |.|:....:::...|..|   ||     |||.
Human   226 -------SIQEMYAAIKADPDGDGVLSLQE-----FSNM-------------------------- 252

  Fly   308 HAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSA-----VAGSGGEGTVRD 367
                              |:..:|..:.|       .:|:..|:||::     ..|.|....:|.
Human   253 ------------------DLRDFHKYMRS-------HKAESSELVRNSHHTWLYQGEGAHHIMRA 292

  Fly   368 L--RVSQQTWLDYKSPVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDY--------- 421
            :  ||.:.|.|   ||      .|::.        :|.:||..||.||.|..|.|.
Human   293 IRQRVLRLTRL---SP------EIVEL--------SEPLQVVRYGEGGHYHAHVDSGPVYPETIC 340

  Fly   422 ------------FE-----------------------------VNLPKNF-EGDR---------- 434
                        ||                             |.:|... .||.
Human   341 SHTKLVANESVPFETSCRQVSPNWGLPSILRPGTPMTQAQPCTVGVPLGMGPGDHWVIPVSPWEH 405

  Fly   435 --------------ISTSMFYLSDVEQGGYTVF---------------------------TKLNV 458
                          ..|.:|||::|..||.|||                           .|.|:
Human   406 PQLGTCSVPPLPYSYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNL 470

  Fly   459 FLPPVKGALVMWHNLHRSLH-----VDARTLHAGCPVIVGSKRIGNIWMH 503
            .:.|.:|..|.|:|......     ||..:||.||.|..|:|.|.|.|::
Human   471 RVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWIN 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	28/145 (19%)
		P4Hc	335..503	CDD:214780	60/281 (21%)
P4HTM	NP_808807.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..111		7/21 (33%)
		EF-hand_7	192..252	CDD:290234	20/89 (22%)
		EFh	194..252	CDD:238008	20/87 (23%)
		P4Hc	246..519	CDD:214780	66/345 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740