Protein Alignment PH4alphaSG2 and P4HA1

DIOPT Version :9

• Sequence 1: NP_651801.1
• Gene: PH4alphaSG2 / 43623
• FlyBaseID: FBgn0039779
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_000908.2
• Gene: P4HA1 / 5033
• HGNCID: 8546
• Length: 534
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 178/540 - (32%)
• Similarity: 283/540 - (52%)
• Gaps: 43/540 - (7%)

  Fly     8 YIGIFQLIIWVGVANGEFYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIKREHE 72
            ||.|..:::...:|:..|::|:..|.||...|::|:.:.:.|:::::.:|:..:::.|::.|...
Human     4 YILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTS 68

  Fly    73 WATSQLKLDDYLGHPLHAFRLIKRLVRDWDSLIFEPILANNAREEFRAFVEVLSRDLGY-PDQSE 136
            .||..  .:.::|||::||:|:|||..:|..|  |.::..:..:   .|:..|:....| |:..:
Human    69 TATKD--PEGFVGHPVNAFKLMKRLNTEWSEL--ENLVLKDMSD---GFISNLTIQRQYFPNDED 126

  Fly   137 LQGAIKGLARLQKVYNLATSDLADGIIGGLNYGSDLRWRECYEIGVQLFDLGEYQRSLEWLQVAF 201
            ..||.|.|.|||..|||.|..::.|.:.|:.:.|.|...:|:|:|...:...:|..:..|::.|
Human   127 QVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQA- 190

  Fly   202 ILLRNSPREEKDADHYLSDIREYASMANFELGNPKKAARLLSQILESQPTHS-AQQTQKYLE--- 262
              ||.....|......:| :.:|.|.|.::.|:..||..|..::||..|.|. |....||.|
Human   191 --LRQLDEGEISTIDKVS-VLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIM 252

  Fly   263 --------SRVPGKNVQETKPS----------WFSNYTRLCQGRRLP-EERSGDPLRC-YLDGKR 307
                    |....::.|:|.|.          ....|..||:|..:. ..|....|.| |.||.|
Human   253 AKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNR 317

  Fly   308 HAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAVAG-SGGEGTVRDLRVS 371
            :..|.|||.:.|.....|.|..:|.::|..:| .|.::..|..:.|:.|.. ..|:.|....|||
Human   318 NPKFILAPAKQEDEWDKPRIIRFHDIISDAEI-EIVKDLAKPRLSRATVHDPETGKLTTAQYRVS 381

  Fly   372 QQTWLD-YKSPVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFEVNLPKNFE---- 431
            :..||. |::||::.:...||.::|.|::.||.:||||||||||||||.|:...:.|..|:
Human   382 KSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKELGT 446

  Fly   432 GDRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVIVGSKR 496
            |:||:|.:||:|||..||.|||.::...:.|.||..|.|:||..|...|..|.||.|||:||:|.
Human   447 GNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKW 511

  Fly   497 IGNIWMHSGYQEFRRPCNLT 516
            :.|.|:|...|||||||.|:
Human   512 VSNKWLHERGQEFRRPCTLS 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	40/135 (30%)
		P4Hc	335..503	CDD:214780	73/173 (42%)
P4HA1	NP_000908.2	P4Ha_N	25..112	CDD:400573	24/93 (26%)
		TPR	205..238		11/33 (33%)
		P4Hc	345..518	CDD:214780	73/173 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820