DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaSG2 and PH4alphaPV

DIOPT Version :9

Sequence 1:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	157/526 - (29%)
Similarity:	257/526 - (48%)	Gaps:	50/526 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LIIWVGVANGE--FYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIKREHEWATS 76
            |::.:..|.||  ..:||..|..|..:|.:|::....|....:|:|...||.:..::.|::.|.|
  Fly    19 LLLLLRQAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRSITSLRLENDKARS 83

  Fly    77 QLKLDDYLGHPLHAFRLIKRLVRDWDSLIF-----EPILANNAR--EEFRAFVEVLSRDLGYPDQ 134
              ..::||.:||::|.||:|:.|||  :|:     :|:..:...  :|.|..:         |..
  Fly    84 --STEEYLSNPLNSFSLIRRMNRDW--IIWQLYMDDPVGISQVERIQELREHM---------PTH 135

  Fly   135 SELQGAIKGLARLQKVYNLATSDLADGIIGGLNYGSDLRWRECYEIGVQLFDLGEYQRSLEWLQV 199
            ::::.|:..|.|:|..|.|...:::.|.:.|..|...|...:.|.:|..|||...|..:..|:..
  Fly   136 TDVEEAVTALDRIQSTYGLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQ 200

  Fly   200 AFILLR----NSPREEKDADHYLSDIREYASMANFELGNPKKAARLLSQILESQPTHSAQQTQKY 260
            :.:|:.    .:|.|...     :::|...:....:|.....|.::::..|...| |..:...|.
  Fly   201 SVVLMEAFSMAAPLEISK-----NEVRMVYAETLLKLNQHADALKVVNIALTDNP-HDIKLLLKK 259

  Fly   261 LE---------SRVPGKNVQETKPSWFSNYTRLCQGRRLPEERSGDPLRCYLDGKRHAYFTLAPL 316
            .|         :..|...||.|...  :.|...|:|:..|...|  .|.|..:.....:..||||
  Fly   260 SEIETMIRTGTNNAPPVKVQATGVP--TAYQIGCRGQFPPSADS--KLYCLYNRTTSPFLILAPL 320

  Fly   317 QVEPVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAVAGSGGEGTVRDLRVSQQTWL-DYKS 380
            ::|.|.|||.:.:||.:||.|:|..:...|.......:....|.|...|...|.|:..|. |..:
  Fly   321 KMELVGLDPYMVLYHDVLSPKEIKELQGMATPGLKRATVYQASSGRNEVVKTRTSKVAWFPDGYN 385

  Fly   381 PVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYF---EVNLPKNFEGDRISTSMFYL 442
            |:...:...|..::||::.|:|.:|:.|||:||.|:.|.|:|   ..|:.. ..||||:|.:|||
  Fly   386 PLTVRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFFNKTNSNMTA-MSGDRIATVLFYL 449

  Fly   443 SDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVIVGSKRIGNIWMHSGYQ 507
            :||||||.|||..:...:.|.:|::|||:||..:..:|.:||||.||||||||.:.|.|:....|
  Fly   450 TDVEQGGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVGSKWVCNKWIREREQ 514

  Fly   508 EFRRPC 513
            .|.|||
  Fly   515 IFSRPC 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	37/141 (26%)
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	67/171 (39%)
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	37/141 (26%)
		TPR_11	179..250	CDD:290150	14/75 (19%)
		TPR repeat	179..213	CDD:276809	8/33 (24%)
		TPR repeat	218..248	CDD:276809	4/34 (12%)
		P4Hc	339..510	CDD:214780	67/171 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461753
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910