DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaSG2 and PH4alphaMP

DIOPT Version :9

Sequence 1:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	556	Identity:	185/556 - (33%)
Similarity:	291/556 - (52%)	Gaps:	52/556 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLDRHCLYIGIFQLIIWVGVANGEFYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVE 65
            ||...|    :..|::.|...:|||:||...:..|.:.|..||...::||....:..:..:..::
  Fly     1 MLLAKC----VLFLVLQVLSCHGEFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEID 61

  Fly    66 QIKREHEWATSQLKLDDYLGHPLHAFRLIKRLVRDWDSLIFE-PILANNAREEFRAFVEVLSRDL 129
            .|:.||..|..  .:||||.:|::||||||||..||::  || .:.|:::|..:...:..|..:|
  Fly    62 AIRVEHLNAAD--GIDDYLNNPVNAFRLIKRLHSDWET--FEGSVTADSSRSNYLDTMASLKENL 122

  Fly   130 GYPDQSELQGAIKGLARLQKVYNLATSDLADGIIGGLNYGSDLRWRECYEIGVQLFDLGEYQRSL 194
            .:|.|.:..|:...|.|||:.|.|..::||.||:.|:.||:.:.|::|:.:|..|:.|.:|..::
  Fly   123 SFPSQDDFVGSAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYNHTV 187

  Fly   195 EWLQVAFILL-RNSPREEKDADHYLSDIREYASMANFELGNPKKAARLLSQILESQP---THSAQ 255
            .|||.:..|| ..|...|..:..::..:.||    :.|:|..:.|..|::.:|..:|   :|..:
  Fly   188 PWLQQSMQLLGEQSYGSESASLDFMEAVVEY----HREMGAHESALSLVNHVLSIEPDQRSHLLE 248

  Fly   256 QTQK--------------YLESRVPGKNVQETKPSWFSNYTRLCQGRRLPEERSGDPLRCYLDGK 306
            ..|:              :|.:|.|| :..|::.  |..|.::|:|...|.......|||.|...
  Fly   249 ARQQLEELITDGDKNGLLHLTARRPG-DYHESRE--FRMYEQVCRGELAPLPSKQRNLRCRLRKS 310

  Fly   307 RHAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAVAGSGGEG--TVRDLR 369
            |..|   ||.::|.:||||.:...|.::.||...|: ::..:..:.||.|...||.|  |....|
  Fly   311 RLGY---APFKLEELHLDPLVVQLHQVIGSKDSDSL-QKTARPRIKRSTVYSLGGNGGSTAAAFR 371

  Fly   370 VSQQTWLDY-KSPVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFEVNLPKN---- 429
            .||....:| ::.....:.|.:...||.:|..||.:||||||:||.||||.|.|    |:|
  Fly   372 TSQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWDSF----PENHIYQ 432

  Fly   430 ---FEGDRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVI 491
               ..|:|::|.::||:|||.||.|.|..|.:.:.|.:|:|:.|:|||.|...|.||.||.|||:
  Fly   433 EGDLHGNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRTKHAACPVL 497

  Fly   492 VGSKRIGNIWMHSGYQEFRRPCNLTSDSYKSLAYRD 527
            .|||.|.|:|:....|:..|||:|......||.|||
  Fly   498 QGSKWIANVWIRERNQDNVRPCDLERGQEISLHYRD 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	44/135 (33%)
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	71/177 (40%)
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	44/135 (33%)
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	71/177 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461825
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900