DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaSG2 and CG18749

DIOPT Version :9

Sequence 1:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	138/524 - (26%)
Similarity:	233/524 - (44%)	Gaps:	111/524 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIKREHEWATSQLKLD--DYLGHP 87
            :.:|...:..|.:||:||::..:.||::.:.:.:...|.:..:.||:    .::|.|  .|||:|
  Fly    32 YAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSREN----MEMKSDYESYLGNP 92

  Fly    88 LHAFRLIKRLVRDWDSLIFEPILANNAREEFRAFVEVLSRDLGY-----------PDQSELQGAI 141
            |::||||.||...|             |:.::..::|.:..||:           |..|:||.|.
  Fly    93 LNSFRLIHRLHTSW-------------RKWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQAC 144

  Fly   142 KGLARLQKVYNLATSDLADGIIGGLNY-GSDLRWRECY---EIGVQLFDLGEYQRSLEWLQVAFI 202
            :|:..|...|:|...:||.|.:.|.:. |:.|...:|.   |.|||
  Fly   145 RGIHDLMYFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFGVQ------------------- 190

  Fly   203 LLRNSPREEKDADHYLSDIRE---YASMANFELGNPKKAARLLSQILESQPTHSA---------Q 255
                   .:||      |:.|   ..|:..|:            .|:|....|.|         |
  Fly   191 -------NQKD------DLAEAWYNLSLTRFD------------NIIEKYQVHKAWALLLAKNKQ 230

  Fly   256 QTQ--KYLESRVPGKNVQETKPSWFSNYTRLCQGRRLPEERSGDPLRCYLDGKRHAYFTLAPLQV 318
            .|:  ::.|:: |...|...:...|.......|......::....|.|..:.....:..:|||::
  Fly   231 LTEAFQHFENK-PEGIVASNEVIHFEGVLATTQNCTAVVQKPSKKLHCRYNTSTTPFTRIAPLKM 294

  Fly   319 EPVHLDPDINVYHGMLSSKQILSIFEEAD--KEEMVRSAVAGSGGEGTVRDLRVSQQTWL-DYKS 380
            |.:.|||.:.|:|.::...:|..:...:|  ..|.|         .|...::|.|:.:.: |.|
  Fly   295 EELGLDPYMVVFHDVIYDTEIDGMLNSSDFGLSESV---------SGLKSEVRTSKDSHIVDAK- 349

  Fly   381 PVMNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFE-VNLPKNFEGDRISTSMFYLSD 444
                ::...:..::|..|..::...:.|||:||.:..|.|:.| .|..:..:||||:|.:|||.:
  Fly   350 ----TLNERVTDMTGLSMEMSDPFSLINYGLGGHFILHHDFHEYTNTTRLKQGDRIATVLFYLRE 410

  Fly   445 VEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVIVGSKRIGNIWMHSGYQEF 509
            |:.||.|||..||:.:.|.||:.|.|:|||.|..|:::|||..||||.|||.:...|::...|.|
  Fly   411 VDSGGATVFPMLNITVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVISGSKYVLTKWINELPQMF 475

  Fly   510 RRPC 513
            ..||
  Fly   476 VTPC 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	41/147 (28%)
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	57/171 (33%)
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	41/147 (28%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	56/167 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461786
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.890