Protein Alignment PH4alphaSG2 and dpy-18

DIOPT Version :10

• Sequence 1: NP_651801.1
• Gene: PH4alphaSG2 / 43623
• FlyBaseID: FBgn0039779
• Length: 527
• Species: Drosophila melanogaster
• Sequence 2: NP_499464.1
• Gene: dpy-18 / 176569
• WormBaseID: WBGene00001077
• Length: 559
• Species: Caenorhabditis elegans
• Alignment Length: 533
• Identity: 155/533 - (29%)
• Similarity: 267/533 - (50%)
• Gaps: 43/533 - (8%)

  Fly    18 VGVANGEFYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIKREHEWATSQLKLDD 82
            :|.|..:.::|:..||:|.:.|..:......|:..::::|...::..|:..:::|.:......|
 Worm    11 IGYAVADLFTSIADMQNLLETERNIPKILDKYIHDEEERLVQLKKLSEEYSKKNEISIENGLKD- 74

  Fly    83 YLGHPLHAFRLIKRLVRDWDSLIFEPILANNAREEFRAFVEVLSRDLGYPDQSELQGAIKGLARL 147
             :.:|::||.||||.:.||.. |...:.||.|.....:..:. |..:.||...:|.||..||.||
 Worm    75 -ITNPINAFLLIKRKIFDWKE-IESKMNANKAGNVVSSITDD-SYGVRYPTADDLSGAAIGLLRL 136

  Fly   148 QKVYNLATSDLADGII----GGLNYGSDLRWRECYEIGVQLFDLGEYQRSLEWLQVAFILLRNSP 208
            |..|.|.|.|||||.|    |...:.:    ::|:||....::..::..::.|::.|    :...
 Worm   137 QDTYRLDTKDLADGKIYADQGNYTFSA----KDCFEIARAAYNEHDFYHTVMWMEEA----QRRL 193

  Fly   209 REEKDADHYLSDIREYASMANFELGNPKKAARLLSQILESQPTH-SAQQTQKYLESRVPGKNV-- 270
            .:|.:....:.||.||.:.|.::..|.|.|.:|..::.:..||| .|:...|:.|..:..:.|
 Worm   194 GDEVEPTVEVEDILEYLAFALYKQNNLKHALKLTEELYKMNPTHPRAKGNVKWYEDLLEQEGVRR 258

  Fly   271 ----------QETKP-SWFSN-----YTRLCQGRRLPEERSGDPLRCYLDGKRHAYFTLAPLQVE 319
                      |..:| |...|     |..||:......::....|.||....| .:...||::||
 Worm   259 SDMRKNLPPIQNRRPDSVLGNTERTMYEALCRNEVPVSQKDISRLYCYYKRDR-PFLVYAPIKVE 322

  Fly   320 PVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAVAGS-GGEGTVRDLRVSQQTWL-DYKSPV 382
            ....:|...::..::|..::.:| :|..|.::.|:.|..| .|:......|:|:..|| :::..|
 Worm   323 IKRFNPLAVLFKDVISDDEVAAI-QELAKPKLARATVHDSVTGKLVTATYRISKSAWLKEWEGDV 386

  Fly   383 MNSVGRIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFEVNLPKNFE----GDRISTSMFYLS 443
            :.:|.:.|.:::..:|..||.:|:||||:||.|:||.|:.:....|:||    |:||:|.:||:|
 Worm   387 VETVNKRIGYMTNLEMETAEELQIANYGIGGHYDPHFDHAKKEESKSFESLGTGNRIATVLFYMS 451

  Fly   444 DVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVIVGSKRIGNIWMHSGYQE 508
            ....||.||||:....:.|.|...:.|:||::....:..|.||.|||:||.|.:.|.|:|....|
 Worm   452 QPSHGGGTVFTEAKSTILPTKNDALFWYNLYKQGDGNPDTRHAACPVLVGIKWVSNKWIHEKGNE 516

  Fly   509 FRRPCNLTSDSYK 521
            |||||.|.|..|:
 Worm   517 FRRPCGLKSSDYE 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG2	NP_651801.1	P4Ha_N	28..165	CDD:462433	43/140 (31%)
		CpoB	<178..263	CDD:441335	19/85 (22%)
		P4Hc	335..503	CDD:214780	61/173 (35%)
dpy-18	NP_499464.1	P4Ha_N	21..152	CDD:462433	42/134 (31%)
		NrfG	150..>240	CDD:443378	21/97 (22%)
		P4Hc	338..511	CDD:214780	61/173 (35%)