DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaSG2 and p4ha3

DIOPT Version :9

Sequence 1:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster
Sequence 2:	XP_031752143.1	Gene:	p4ha3 / 100495824	XenbaseID:	XB-GENE-962355	Length:	547	Species:	Xenopus tropicalis

Alignment Length:	529	Identity:	168/529 - (31%)
Similarity:	256/529 - (48%)	Gaps:	50/529 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ANGEFYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIKREHEWATSQLKLDDYLG 85
            |..:.|||:.|:|....:|..||.....|::.:.::|...||:.|:::..|:.....::
Frog    27 AGADMYSSMASIQQAVGMEGALLQHLGQYLQQETQRLSDLRRFYEKVQASHQAGGPPVQ------ 85

  Fly    86 HPLHAFRLIKRLVRDWDSLIFEPILANNAREEFRAF---VEVLSRDLGYPDQSELQGAIKGLARL 147
            .|:.|:.|:|||..:|.:::.    ::.|.|..:|.   .|.:.:||..|:  :::||.|.|.||
Frog    86 DPILAYTLLKRLQSEWMNVVH----SSEANENIQALKEGYEKVKQDLPAPE--DVEGAAKALMRL 144

  Fly   148 QKVYNLATSDLADGII-------GGLNYG----SDLRWRECYEIGVQLFDLGEYQRSLEWLQVAF 201
            |.||:|..:.||.|:.       ..|.|.    |.:...:|:.||...:|:.:|..|:.||:.|.
Frog   145 QDVYSLNVNGLARGMFQRSSSSDTKLLYNPPHLSIMSADDCFHIGKVAYDMEDYYHSIPWLEEAV 209

  Fly   202 ILLRNSPREEKDADH-YLSDIREYASMANFELGNPKKAARLLSQILESQPTHS--AQQTQKY--- 260
            ...|.|....:..|. .|.:..:|.:.:.::.||...|..|..:.|...|.:.  |:...||
Frog   210 SRFRGSYGNWRTEDEGSLEEALDYLAFSYYKAGNISHALDLSRECLLYDPDNGRLARNIAKYEQI 274

  Fly   261 -LESRVPGKNVQETK---PSWFSNYTR-----LCQGRRLPEERSGDP-LRCYLDGKRHAYFTLAP 315
             .||.....:.:|.|   |:.....||     |||..........|| :.|..|...|.|..|.|
Frog   275 LYESPTADADAEEMKLQRPNVTHLKTRDLYEGLCQTLGSQPTSYEDPHMSCMYDTNSHPYLLLQP 339

  Fly   316 LQVEPVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAVAGSGGEGTVRDLRVSQQTWL-DYK 379
            ::.|.|.|.|.:.:||..:|..:...|.|.|  ...:..:|..||.:....:.|:|:..|| |..
Frog   340 MKKEIVSLRPQVVLYHDFVSDLEAEKIKELA--SPWLHRSVVASGEKQAEAEYRISKSAWLKDTI 402

  Fly   380 SPVMNSVGRIIQFVSGFDM--AGAEHMQVANYGVGGQYEPHPDYF---EVNLPKNFEGDRISTSM 439
            .|.:.::...|..|:|.:.  ..||::||.|||:||.||||.|:.   :..|.:...|:|::|.|
Frog   403 HPFVQNLDTRISAVTGLNAHPPYAEYLQVVNYGIGGHYEPHFDHATSRKSPLYRTNTGNRLATFM 467

  Fly   440 FYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVIVGSKRIGNIWMHS 504
            .|||.|:.||.|.|...|...|.||.|.|.|.||||:...|..|||||||||:|||.:.|.|:|.
Frog   468 IYLSHVDLGGSTAFVFANFSSPVVKNAAVFWWNLHRNGLGDEDTLHAGCPVIIGSKWVANKWIHE 532

  Fly   505 GYQEFRRPC 513
            ..|||.|||
Frog   533 FGQEFHRPC 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	39/137 (28%)
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	69/173 (40%)
p4ha3	XP_031752143.1	P4Ha_N	35..>104	CDD:400573	18/74 (24%)
		TPR repeat	182..210	CDD:276809	9/27 (33%)
		TPR repeat	215..257	CDD:276809	9/41 (22%)
		P4Hc	359..531	CDD:214780	69/173 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.000