DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaEFB and p4htma

DIOPT Version :9

Sequence 1:	NP_733371.1	Gene:	PH4alphaEFB / 43620	FlyBaseID:	FBgn0039776	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001074160.1	Gene:	p4htma / 791209	ZFINID:	ZDB-GENE-070112-2222	Length:	478	Species:	Danio rerio

Alignment Length:	343	Identity:	68/343 - (19%)
Similarity:	115/343 - (33%)	Gaps:	85/343 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 LQLRKMKGDDGTDEMPKSDLPVAKSDPAIFDMTERRAYEMLCRGELKP----------SPSDLRS 319
            :||.::||...:..:...|.....:...:|.:.:.....:|.|.|:..          |..:||.
Zfish   158 MQLAQLKGLTHSSLLTNPDQEEQLTQDELFSLLDLNQDGLLQREEILSLSHSTDGSWLSSYNLRK 222

  Fly   320 LRCRYVTNRVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTGAL 384
            :.....||     ..|.|.|:|                     .||::....|.:.....:.|..
Zfish   223 IHTGLETN-----PSGVLSLQE---------------------FKRVSGGVLRYSGAAQGLDGHT 261

  Fly   385 ETANYRISKSAWLKTQEDRVIETVVQRTADMTGLD---MDSAEELQVVNYGIGGHYEPHFDFARK 446
            :..........:|......::::|..|...:|.|.   :|.:|.::||.|..|.....|.|.:..
Zfish   262 KVRQRSTHTRLYLGEGTHHLLKSVRNRVTRLTRLPSSLVDLSEAMEVVRYEQGVFSHAHHDSSPT 326

  Fly   447 EEQRAFE----GLNLGNRIA----TVLFYMSDVEQGGATVFTSLHTALF---------------- 487
            ....:..    ..|..|::|    |||.|::..:.||.|.|.......:
Zfish   327 HPDNSCTHTHLAANTSNQVACRYLTVLLYLNSADSGGETSFPVADNRTYEEEVLGDLSQQYCDKG 391

  Fly   488 -----PKKGTAAFWMNLHRDGQG-----DVRTRHAACPVLTGTKWVSNKWIH-----ERGQEFRR 537
                 |..|||..|.|...||.|     |..:.|..|.|..|.||..:.|::     :|.:.::|
Zfish   392 NLKVKPVAGTALLWYNHLSDGNGWVGELDEFSLHGDCLVTRGFKWTGSVWVNIDPDQQRQERYQR 456

  Fly   538 PCDLE-------EDHGEF 548
            .....       .:||:|
Zfish   457 LVSWHPEGHSKTPEHGDF 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528
PH4alphaEFB	NP_733371.1	P4Hc	356..529	CDD:214780	45/209 (22%)
p4htma	NP_001074160.1	2OG-FeII_Oxy	<272..442	CDD:304390	40/169 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740