DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaEFB and CG34345

DIOPT Version :9

Sequence 1:	NP_733371.1	Gene:	PH4alphaEFB / 43620	FlyBaseID:	FBgn0039776	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	153/545 - (28%)
Similarity:	264/545 - (48%)	Gaps:	108/545 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VYT-ALAEMEELLETESVLITNLEGYIRVQEDKL------------NFLKNKMDEYQREHSDASH 76
            :|: ::..:.||.|.|:..:.:|..|:...:.|:            |:|.:|:|.|:
  Fly    36 IYSNSIRALSELREIENSYMEHLNNYVSFLQQKIKTLRIFINSLTPNYLDHKVDRYK-------- 92

  Fly    77 DITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVGTDFLQNITQYRSLL-KFPSDEDLNGAAVAL 140
                |||||:|::.|.:|...||.::...:: |.| :...:|.:...|: :.|...|:..|.:.:
  Fly    93 ----YVSNPLNSFGLLRRAHQDWPKLIAYLK-DQG-NIKVDIEEMNKLINRTPHANDMEEALMGM 151

  Fly   141 LRLQDTYQLDTSSVARGKLNGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWMNEAMARMLEEPT 205
            .|::..|.|.:|.:|:|.:.|.|.|:.||:.||..|....|...::.....|...|::...:...
  Fly   152 DRIEHFYDLKSSDMAQGLVAGQQLSSRMSASDCLALADYMYKRSEFRRAAEWYRIALSVFTKPKN 216

  Fly   206 NHTQSF---TKADILEYLAFSTYKEGNIESALTMTNELLQLLPHHERANGNKRFYEKEIAQQLQL 267
            |....|   .:.::.:....|..:||::|:   :|:.|                  ||::|
  Fly   217 NIAFKFYAPKRKELEKMFVISRLQEGSVEN---LTDCL------------------KELSQ---- 256

  Fly   268 RKMKGDDGTDEMPKSDLPVAKSDP--AIFDMTERRAYEML---CRGELKPSPSDLRSLRCRYVTN 327
                                  ||  ::..:..|::..|:   |:|:..|.|    .|.|||.:.
  Fly   257 ----------------------DPNNSLVHLRPRKSPTMIEQGCQGKFPPGP----QLVCRYNST 295

  Fly   328 RVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTGALETANY--- 389
            ..||:|:.|||.||:..||.|.:|||.:|||||..:..:.|        :..:.|.  |.||
  Fly   296 TTPFMRIAPLKEEEISRDPLIWLYHDVIYDSEIAQLTNVTR--------EEMILGT--TTNYTTP 350

  Fly   390 -RISKSAWLKTQED---RVIETVVQRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARKEEQR 450
             |:::...:|..:|   ::.:|:|.|.||::|||:.:...|..:|||:||:::.|.|:.   :.:
  Fly   351 DRVNRLFHIKVTDDDGGKLDKTLVNRMADISGLDVGNTTTLARINYGLGGYFQEHSDYM---DIK 412

  Fly   451 AFEGL-NLGNRIATVLFYMSDVEQGGATVFTSLHTALFPKKGTAAFWMNLHRDGQGDVRTRHAAC 514
            .:..| ..|:|:.|.||||:||..||.|:|.....|:.||||:|.||.|||.:|..::.||||.|
  Fly   413 LYPELTEEGDRLMTFLFYMTDVPVGGTTIFPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAVC 477

  Fly   515 PVLTGTKWVSNKWIHERGQEFRRPC 539
            |.:.|::||..|.:....|.|::||
  Fly   478 PTIVGSRWVLVKSMLNYEQMFKKPC 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528	35/143 (24%)
PH4alphaEFB	NP_733371.1	P4Hc	356..529	CDD:214780	65/180 (36%)
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	35/143 (24%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	64/177 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461813
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900