DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaEFB and p4ha1a

DIOPT Version :9

Sequence 1:	NP_733371.1	Gene:	PH4alphaEFB / 43620	FlyBaseID:	FBgn0039776	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	XP_009304776.1	Gene:	p4ha1a / 562774	ZFINID:	ZDB-GENE-040724-91	Length:	541	Species:	Danio rerio

Alignment Length:	537	Identity:	258/537 - (48%)
Similarity:	353/537 - (65%)	Gaps:	16/537 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILLLVGGPANGEVYTALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMDEYQREHSDASHD 77
            |.||....|:.:.:|::..|.:||.||..|:|:|:.||:.:|.||..:|...::.....:.|..|
Zfish    13 ISLLKSSSAHSDFFTSIGHMTDLLFTEKDLVTSLKDYIKAEESKLEQVKQWAEKLDALTATAVQD 77

  Fly    78 ITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVGTDFLQNITQYRSLLKFPSDEDLNGAAVALLR 142
            ...::.:|:||:.|.|||.|:|.:||:|:..|:...|:.|:|..|..  ||:|||.||||.||||
Zfish    78 PEGFLGHPVNAFKLMKRLNTEWGEVEDLVLKDMSDGFISNLTIQRQY--FPNDEDQNGAAKALLR 140

  Fly   143 LQDTYQLDTSSVARGKL----NGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWMNEAMARMLEE 203
            |||||:|||.:::.|.|    .|:.|.:.::.:||||||:.:|.:.|||||.|||.:|: :.|:|
Zfish   141 LQDTYKLDTQTISSGDLPGVNTGLPYKSTLTVEDCFELGKIAYSDADYYHTELWMAQAL-KQLDE 204

  Fly   204 PTNHTQSFTKADILEYLAFSTYKEGNIESALTMTNELLQLLPHHERANGNKRFYEKEIAQQLQLR 268
              ....|...|..|:||::|.|::|.:|.||..|..||.:.|.|:||.||.::::.::|:|   :
Zfish   205 --GEESSVEIATALDYLSYSVYQQGELERALEYTKRLLTVEPEHQRALGNLKYFDYQLAKQ---K 264

  Fly   269 KMKGDDGTDEMPKSDLPVAKSDPAIFDMTERRAYEMLCRGE-LKPSPSDLRSLRCRYVT-NRVPF 331
            |.:.:..|.|..|.:...  ||.....:.|:|.||.||||| ||.:|...:.|.|||.. ||.||
Zfish   265 KAEKEQSTKEESKKEQET--SDGKKEYLPEKRKYEKLCRGEGLKMTPRRQKHLFCRYFNGNRHPF 327

  Fly   332 LRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTGALETANYRISKSAW 396
            ..:||:|.|:....|.|:.||:.:.:.||:.||.:::||.||||:.|.:||.||||:||||||||
Zfish   328 YTIGPVKQEDEWDRPRIIRYHEIITEQEIEKIKELSKPRLRRATISNPITGVLETAHYRISKSAW 392

  Fly   397 LKTQEDRVIETVVQRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARKEEQRAFEGLNLGNRI 461
            |...|..|::.:.||..|:|||::.:||||||.|||:||.|||||||.||:|..||:.|..||||
Zfish   393 LAAYEHPVVDRINQRIEDITGLNVKTAEELQVANYGVGGQYEPHFDFGRKDEPDAFKELGTGNRI 457

  Fly   462 ATVLFYMSDVEQGGATVFTSLHTALFPKKGTAAFWMNLHRDGQGDVRTRHAACPVLTGTKWVSNK 526
            ||.|||||||..||||||..:..|:.|.||||.||.||...|:||..|||||||||.|.||||||
Zfish   458 ATWLFYMSDVAAGGATVFPEVGAAVKPLKGTAVFWYNLFPSGEGDYSTRHAACPVLVGNKWVSNK 522

  Fly   527 WIHERGQEFRRPCDLEE 543
            |||||||||||||.|:|
Zfish   523 WIHERGQEFRRPCGLKE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528	55/130 (42%)
PH4alphaEFB	NP_733371.1	P4Hc	356..529	CDD:214780	107/172 (62%)
p4ha1a	XP_009304776.1	P4Ha_N	28..157	CDD:285528	55/130 (42%)
		TPR repeat	172..207	CDD:276809	18/37 (49%)
		TPR repeat	212..242	CDD:276809	13/29 (45%)
		Fis1	218..262	CDD:304536	17/43 (40%)
		P4Hc	352..525	CDD:214780	107/172 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583426
Domainoid	1	1.000	206	1.000	Domainoid score	I2855
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30998
Inparanoid	1	1.050	491	1.000	Inparanoid score	I1373
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		otm25034
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770