Protein Alignment PH4alphaEFB and P4HA1

DIOPT Version :10

• Sequence 1: NP_733371.1
• Gene: PH4alphaEFB / 43620
• FlyBaseID: FBgn0039776
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_000908.2
• Gene: P4HA1 / 5033
• HGNCID: 8546
• Length: 534
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 261/543 - (48%)
• Similarity: 366/543 - (67%)
• Gaps: 22/543 - (4%)

  Fly     8 MLLLGILLLVGGP---ANGEVYTALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMDEYQR 69
            :|::||||    |   |:...:|::.:|.:|:.||..|:|:|:.||:.:||||..:|...::..|
Human     5 ILIIGILL----PQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDR 65

  Fly    70 EHSDASHDITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVGTDFLQNITQYRSLLKFPSDEDLN 134
            ..|.|:.|...:|.:|:||:.|.|||.|:|.::|||:..|:...|:.|:|..|..  ||:|||..
Human    66 LTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY--FPNDEDQV 128

  Fly   135 GAAVALLRLQDTYQLDTSSVARGKLNGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWMNEAMAR 199
            |||.|||||||||.|||.::::|.|.|:::.:.::::||||||:.:|...|||||.|||.:|: |
Human   129 GAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQAL-R 192

  Fly   200 MLEEPTNHTQSFTKADILEYLAFSTYKEGNIESALTMTNELLQLLPHHERANGNKRFYEKEIAQQ 264
            .|:|  ....:..|..:|:||:::.|::|:::.||.:|.:||:|.|.|:|||||.:::|..:|::
Human   193 QLDE--GEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKE 255

  Fly   265 LQLRKMKGDDGTDE--MPKSDLPVAKSDPAIFDMTERRAYEMLCRGE-LKPSPSDLRSLRCRYVT 326
            ..:.|...||.:|:  .||      |...|:..:.||:.|||||||| :|.:|...:.|.|||..
Human   256 KDVNKSASDDQSDQKTTPK------KKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHD 314

  Fly   327 -NRVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTGALETANYR 390
             ||.|...|.|.|.|:....|.|:.:||.:.|:||:::|.:|:||..||||.:..||.|.||.||
Human   315 GNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYR 379

  Fly   391 ISKSAWLKTQEDRVIETVVQRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARKEEQRAFEGL 455
            :||||||...|:.|:..:..|..|:||||:.:||||||.|||:||.||||||||||:|..||:.|
Human   380 VSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKEL 444

  Fly   456 NLGNRIATVLFYMSDVEQGGATVFTSLHTALFPKKGTAAFWMNLHRDGQGDVRTRHAACPVLTGT 520
            ..||||||.|||||||..||||||..:..:::||||||.||.||...|:||..|||||||||.|.
Human   445 GTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGN 509

  Fly   521 KWVSNKWIHERGQEFRRPCDLEE 543
            |||||||:|||||||||||.|.|
Human   510 KWVSNKWLHERGQEFRRPCTLSE 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..161	CDD:462433	58/132 (44%)
		P4Hc	356..529	CDD:214780	106/172 (62%)
P4HA1	NP_000908.2	P4Ha_N	24..155	CDD:462433	58/132 (44%)
		TPR	205..238		12/32 (38%)
		P4Hc	345..518	CDD:214780	106/172 (62%)