Protein Alignment PH4alphaEFB and P4HA1

DIOPT Version :9

• Sequence 1: NP_733371.1
• Gene: PH4alphaEFB / 43620
• FlyBaseID: FBgn0039776
• Length: 550
• Species: Drosophila melanogaster
• Sequence 2: NP_000908.2
• Gene: P4HA1 / 5033
• HGNCID: 8546
• Length: 534
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 261/543 - (48%)
• Similarity: 366/543 - (67%)
• Gaps: 22/543 - (4%)

  Fly     8 MLLLGILLLVGGP---ANGEVYTALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMDEYQR 69
            :|::||||    |   |:...:|::.:|.:|:.||..|:|:|:.||:.:||||..:|...::..|
Human     5 ILIIGILL----PQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDR 65

  Fly    70 EHSDASHDITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVGTDFLQNITQYRSLLKFPSDEDLN 134
            ..|.|:.|...:|.:|:||:.|.|||.|:|.::|||:..|:...|:.|:|..|..  ||:|||..
Human    66 LTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY--FPNDEDQV 128

  Fly   135 GAAVALLRLQDTYQLDTSSVARGKLNGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWMNEAMAR 199
            |||.|||||||||.|||.::::|.|.|:::.:.::::||||||:.:|...|||||.|||.:|: |
Human   129 GAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQAL-R 192

  Fly   200 MLEEPTNHTQSFTKADILEYLAFSTYKEGNIESALTMTNELLQLLPHHERANGNKRFYEKEIAQQ 264
            .|:|  ....:..|..:|:||:::.|::|:::.||.:|.:||:|.|.|:|||||.:::|..:|::
Human   193 QLDE--GEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKE 255

  Fly   265 LQLRKMKGDDGTDE--MPKSDLPVAKSDPAIFDMTERRAYEMLCRGE-LKPSPSDLRSLRCRYVT 326
            ..:.|...||.:|:  .||      |...|:..:.||:.|||||||| :|.:|...:.|.|||..
Human   256 KDVNKSASDDQSDQKTTPK------KKGVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHD 314

  Fly   327 -NRVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQNSVTGALETANYR 390
             ||.|...|.|.|.|:....|.|:.:||.:.|:||:::|.:|:||..||||.:..||.|.||.||
Human   315 GNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYR 379

  Fly   391 ISKSAWLKTQEDRVIETVVQRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARKEEQRAFEGL 455
            :||||||...|:.|:..:..|..|:||||:.:||||||.|||:||.||||||||||:|..||:.|
Human   380 VSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFKEL 444

  Fly   456 NLGNRIATVLFYMSDVEQGGATVFTSLHTALFPKKGTAAFWMNLHRDGQGDVRTRHAACPVLTGT 520
            ..||||||.|||||||..||||||..:..:::||||||.||.||...|:||..|||||||||.|.
Human   445 GTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGN 509

  Fly   521 KWVSNKWIHERGQEFRRPCDLEE 543
            |||||||:|||||||||||.|.|
Human   510 KWVSNKWLHERGQEFRRPCTLSE 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528	57/130 (44%)
		P4Hc	356..529	CDD:214780	106/172 (62%)
P4HA1	NP_000908.2	P4Ha_N	25..112	CDD:400573	33/86 (38%)
		TPR	205..238		12/32 (38%)
		P4Hc	345..518	CDD:214780	106/172 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2678
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30998
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1290
Isobase	1	0.950	-	0	Normalized mean entropy	S3137
OMA	1	1.010	-	-		QHG52324
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		otm40771
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	LDO	PTHR10869
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2705
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.860