DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaEFB and PH4alphaMP

DIOPT Version :9

Sequence 1:	NP_733371.1	Gene:	PH4alphaEFB / 43620	FlyBaseID:	FBgn0039776	Length:	550	Species:	Drosophila melanogaster
Sequence 2:	NP_524594.2	Gene:	PH4alphaMP / 43624	FlyBaseID:	FBgn0026190	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	212/545 - (38%)
Similarity:	314/545 - (57%)	Gaps:	39/545 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LMLLLGILLLVGGPANGEVYTALAEMEELLETESVLITNLEGYIRVQEDKLNFLKNKMDEYQREH 71
            |.|:|.:|     ..:||.:::.:.:.:|.|||.||:..|:.|:.........|::::|..:.||
  Fly     8 LFLVLQVL-----SCHGEFFSSTSGLAKLFETEVVLLAELQNYVNEINQHAEALQSEIDAIRVEH 67

  Fly    72 SDASHDITAYVSNPINAYLLTKRLTTDWRQVENLMEHDVG-TDFLQNITQYRSLLKFPSDEDLNG 135
            .:|:..|..|::||:||:.|.|||.:||...|..:..|.. :::|..:...:..|.|||.:|..|
  Fly    68 LNAADGIDDYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMASLKENLSFPSQDDFVG 132

  Fly   136 AAVALLRLQDTYQLDTSSVARGKLNGIQYSTEMSSDDCFELGRQSYVNHDYYHTVLWMNEAMARM 200
            :|:||.|||.|||||.:.:|.|.|||::|.|.||..|||.||:..|...||.|||.|:.::| ::
  Fly   133 SAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVLGQHLYALRDYNHTVPWLQQSM-QL 196

  Fly   201 LEEPTNHTQS----FTKADILEYLAFSTYKE-GNIESALTMTNELLQLLPHHERANGNKRFYEKE 260
            |.|.:..::|    |.:| ::||     ::| |..||||::.|.:|.:.|       ::|.:..|
  Fly   197 LGEQSYGSESASLDFMEA-VVEY-----HREMGAHESALSLVNHVLSIEP-------DQRSHLLE 248

  Fly   261 IAQQLQLRKMKGDDGTDEMPKSDL--PVAKSDPAIFDMTERRAYEMLCRGELKPSPSDLRSLRCR 323
            ..|||:.....||       |:.|  ..|:......:..|.|.||.:|||||.|.||..|:||||
  Fly   249 ARQQLEELITDGD-------KNGLLHLTARRPGDYHESREFRMYEQVCRGELAPLPSKQRNLRCR 306

  Fly   324 YVTNRVPFLRLGPLKLEEVHADPYIVIYHDAMYDSEIDLIKRMARPRFRRATVQN-SVTGALETA 387
            ...:|:.:   .|.||||:|.||.:|..|..:...:.|.:::.||||.:|:||.: ...|....|
  Fly   307 LRKSRLGY---APFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPRIKRSTVYSLGGNGGSTAA 368

  Fly   388 NYRISKSAWLKTQEDRVIETVVQRTADMTGLDMDSAEELQVVNYGIGGHYEPHFDFARKEEQRAF 452
            .:|.|:.|......:...:.:.:...|.:||:||.||:|||.|||||||||||:| :..|.....
  Fly   369 AFRTSQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGIGGHYEPHWD-SFPENHIYQ 432

  Fly   453 EGLNLGNRIATVLFYMSDVEQGGATVFTSLHTALFPKKGTAAFWMNLHRDGQGDVRTRHAACPVL 517
            ||...|||:||.::|::|||.||.|.|..|...:.|::|:..||.|||..|..|.||:|||||||
  Fly   433 EGDLHGNRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWYNLHPSGDQDFRTKHAACPVL 497

  Fly   518 TGTKWVSNKWIHERGQEFRRPCDLE 542
            .|:||::|.||.||.|:..||||||
  Fly   498 QGSKWIANVWIRERNQDNVRPCDLE 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaEFB	NP_733371.1	P4Ha_N	28..159	CDD:285528	47/131 (36%)
PH4alphaEFB	NP_733371.1	P4Hc	356..529	CDD:214780	75/173 (43%)
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	47/131 (36%)
PH4alphaMP	NP_524594.2	P4Hc	336..509	CDD:214780	75/173 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461833
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900